Topic
Triazene
About: Triazene is a research topic. Over the lifetime, 759 publications have been published within this topic receiving 8714 citations. The topic is also known as: Triazene cleavage & 1-triazene.
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TL;DR: A series of 4-hydroxy-3,4-dihydro-1,2,3-benzotriazines ("triazinols") have been investigated for anti-tumor activity and have been found to have marginal activity against the TLX5 tumor.
Abstract: A series of 4-hydroxy-3,4-dihydro-1,2,3-benzotriazines ("triazinols"), potential pro-drugs for the cytotoxic monoalkyltriazenes, have been investigated for anti-tumor activity and have been found to have marginal activity against the TLX5 tumor. The in vivo anti-tumor activity correlates with previously observed in vitro cytotoxicity of the compounds. The chemical behaviour of the triazinols is consistent with carbinolamine triazene ring-chain tautomerism in solution. The triazinols undergo methanolysis to give a series of new 4-methoxytriazines; the rate of methanolysis is primarily dependent on the substituent at C-4 of the triazinol. Those triazinols that undergo methanolysis rapidly are also more active biologically, suggesting that cytotoxicity and anti-tumor activity derive from the insitu generation of the open chain triazene.
6 citations
TL;DR: None of the triazenylimidazole-4-carbonitriles were active against lymphatic leukemia L-1210 im mice, and like the analogous carboxamide, the bis(2-chloroethyl) triazene readily cyclizes to the 1, 2, 3-triazolinium chloride.
6 citations
TL;DR: In this article, a planar planar anthraquinone fragment was inserted between the parallel pairs of nucleic acids for the preparation of alkyltriazene derivatives of 9,10-anthraquinones.
Abstract: Some alkyltriazenes are used in clinical practice as cytotoxic drugs in chemotherapy of cancer [1–4]. Amino derivatives of 9,10-anthraquinone possess similar properties, they inhibit the tumor growth through intercalation, the insertion of a planar anthraquinone fragment between the parallel pairs of nucleic acids [5, 6]. The target of this work was the preparation of alkyltriazene derivatives of 9,10anthraquinone combining presumably the useful qualities of these classes of compounds.
6 citations
TL;DR: In this paper, the effect of monomer/sodium nitrite ratio on the solubility of the polymers, as well as the dependence of properties such as electrical conductivity and ESR upon the main chain structure, have been investigated.
6 citations
TL;DR: In this paper, the thermal decomposition of 1-(o-carbethoxyphenyl)-3-cyanophenyl)-triazene (4) in aqueous ethanol has been found to give 2-phenylquinazolin-4(3H)-one (8); the formation of triazine intermediates in the reaction has been established.
Abstract: The thermal decomposition of 1-(o-carbethoxyphenyl)-3-(o-cyanophenyl)-triazene (4) in aqueous ethanol has been found to give 2-phenylquinazolin-4(3H)-one (8); the formation of triazine intermediates in the reaction has been established.
5 citations