Triphenyl phosphate

About: Triphenyl phosphate is a research topic. Over the lifetime, 579 publications have been published within this topic receiving 6681 citations. The topic is also known as: phenyl phosphate & TPP.

Video Display Units: An Emission Source of the Contact Allergenic Flame Retardant Triphenyl Phosphate in the Indoor Environment

Abstract: Triphenyl phosphate, an additive flame retardant with documented contact allergenic effects on humans, was identified in a computerized indoor office environment. The source of emission was found to be the computer video display units (VDUs). Eighteen VDUs were examined, and the outer covers were shown to contain triphenyl phosphate in levels up to 10% (w/w). When using this type of PC equipment with a brand-new VDU in a small office room, the air concentration of triphenyl phosphate raised to near 100 ng/m3 after 1 day of operation. The measurements were performed in the breathing zone of an imaginary operator sitting in front of the computer. After 1 week of continuous operation, the concentration of triphenyl phosphate was reduced by half. Furthermore, a decrease to approximately 10 ng/m3 could be observed after 183 days, which corresponds to more than 2 yr of ordinary business hour operation.

Stable Covalent Organic Frameworks as Efficient Adsorbents for High and Selective Removal of an Aryl-Organophosphorus Flame Retardant from Water

Abstract: A critical challenge in environmental remediation is the design of adsorbents with proper pore size for the removal of organic pollutants. Three covalent organic frameworks (COFs) with different pore sizes were successfully prepared by a room-temperature solution–suspension method and used to remove a typical aryl-organophosphorus flame retardant [triphenyl phosphate (TPhP)] from aqueous solution. The prepared COFs showed strong acid resistance and thermal stability. The 1,3,5-triformylphloroglucinol (TFP) reacted with benzidine (BD) (COF2) and exhibited the highest sorption capacity for TPhP, followed by the reaction of TFP and 4,4″-diamino-p-terphenyl (DT) (COF3), and the reaction of TFP and p-phenylenediamine (COF1). Their adsorption equilibriums were achieved within 12 h, and COFs with a larger pore size have higher initial sorption rate but longer time to reach sorption equilibrium. According to the Langmuir fitting, the maximum sorption capacities of three COFs for TPhP were 86.1, 387.2, and 371.2 m...

TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver

Abstract: Triphenyl phosphate is a high production volume organophosphate flame retardant that has been detected in multiple environmental media at increasing concentrations. The environmental and health risks of triphenyl phosphate have drawn attention because of the multiplex toxicity of this chemical compound. However, few studies have paid close attention to the impacts of triphenyl phosphate on liver metabolism. We investigated hepatic histopathological, metabolomic and transcriptomic responses of zebrafish after exposure to 0.050 mg/L and 0.300 mg/L triphenyl phosphate for 7 days. Metabolomic analysis revealed significant changes in the contents of glucose, UDP-glucose, lactate, succinate, fumarate, choline, acetylcarnitine, and several fatty acids. Transcriptomic analysis revealed that related pathways, such as the glycosphingolipid biosynthesis, PPAR signaling pathway and fatty acid elongation, were significantly affected. These results suggest that triphenyl phosphate exposure markedly disturbs hepatic carbohydrate and lipid metabolism in zebrafish. Moreover, DNA replication, the cell cycle, and non-homologous end-joining and base excision repair were strongly affected, thus indicating that triphenyl phosphate hinders the DNA damage repair system in zebrafish liver cells. The present study provides a systematic analysis of the triphenyl phosphate-induced toxic effects in zebrafish liver and demonstrates that low concentrations of triphenyl phosphate affect normal metabolism and cell cycle.