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Triphenyl phosphate

About: Triphenyl phosphate is a research topic. Over the lifetime, 579 publications have been published within this topic receiving 6681 citations. The topic is also known as: phenyl phosphate & TPP.


Papers
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Journal ArticleDOI
TL;DR: Insight is provided into the biological fate of ITP and TBPP isomers in human tissues and is useful in identifying appropriate biomarkers of exposure to monitor, particularly in support of epidemiological studies.
Abstract: Isopropylated and tert-butylated triarylphosphate esters (ITPs and TBPPs, respectively) are plasticizers and flame retardants that are ubiquitous in indoor environments; however, no studies to date have characterized their metabolism. Using human liver subcellular S9 fractions, phase I and II in vitro metabolism of triphenyl phosphate (TPHP), 4-tert-butylphenyl diphenyl phosphate (4tBPDPP), 2-isopropylphenyl diphenyl phosphate (2IPPDPP), and 4-isopropylphenyl diphenyl phosphate (4IPPDPP) was investigated at 1 and 10 μM doses. Parent depletion and the formation of known or suspected metabolites (e.g., likely hydrolysis or hydroxylated products), including diphenyl phosphate (DPHP), hydroxyl-triphenyl phosphate (OH-TPHP), isopropylphenyl phenyl phosphate (ip-PPP), and tert-butylphenyl phenyl phosphate (tb-PPP), were monitored and quantified via GC/MS or LC-MS/MS. tb-PPP and its conjugates were identified as the major in vitro metabolites of 4tBPDPP and accounted for 71% and 49%, respectively, of the parent molecule that was metabolized during the incubation. While the mass balance between parents and metabolites was conserved for TPHP and 4tBPDPP, approximately 20% of the initial parent mass was unaccounted for after quantifying suspected metabolites of 2IPPDPP and 4IPPDPP that had authentic standards available. Two novel ITP metabolites, mono-isopropenylphenyl diphenyl phosphate and hydroxy-isopropylphenyl diphenyl phosphate, were tentatively identified by high-resolution mass spectrometry and screened for in recently collected human urine where mono-isopropenylphenyl diphenyl phosphate was detected in one of nine samples analyzed. This study provides insight into the biological fate of ITP and TBPP isomers in human tissues and is useful in identifying appropriate biomarkers of exposure to monitor, particularly in support of epidemiological studies.

11 citations

Journal ArticleDOI
TL;DR: The inhibitory effects of 13 organophosphate esters and hydrolytic metabolites on the carboxylesterase activity of rat liver microsomes in vitro was investigated to examine whether there might be a potential impact on human health, and to elucidate the structure activity relationship.

11 citations

Patent
29 Mar 2007
TL;DR: In this paper, a flame retardant adhesive pressure sensitive adhesive containing a blend of flame retardants is provided, which includes metal oxide, metal hydrate, halogenated material, and a liquid phosphorous-bromine containing composition comprising a triaryl phosphate ester having low triphenyl phosphate content.
Abstract: A flame retardant adhesive pressure sensitive adhesive containing a blend of flame retardants is provided. The flame retardant blend comprises (a) at least one metal oxide; (b) at least one metal hydrate; (c) at least one halogenated material; and (d) a liquid phosphorous-bromine containing composition comprising a triaryl phosphate ester having low triphenyl phosphate content.

11 citations

Patent
03 Apr 2007
TL;DR: Improved flame retardant additives are formed from bis(alkanoic acid ester) of a ring-brominated aromatic diester diol, and liquid alkylated triphenyl phosphate having an approximate average formula (RxPhO)3P=O) in which each R is, independently, a hydrogen atom or a C14 alkyl group and x is an average number in the range of about 0.2 to 3 as mentioned in this paper.
Abstract: Improved flame retardant additives are formed from (A) at least one bis(alkanoic acid ester) of a ring-brominated aromatic diester diol; (B) liquid alkylated triphenyl phosphate having an approximate average formula (RxPhO)3P=O) in which each R is, independently, a hydrogen atom or a C14 alkyl group and x is an average number in the range of about 0.2 to 3; and (C) at least one alicyclic phosphonate ester having 1, 2 or 3 phosphorus atoms in the molecule, at least one of which is part of an alicyclic ring system, and having a phosphorus content of at least about 15 wt%. Combinations of these components are well- suited for use in various polymers or resins, especially polyurethanes.

11 citations

Patent
02 Oct 2013
TL;DR: In this paper, a multifunctional polymethylmethacrylate (PMM) is described, which includes polymethyl methacrylation and additives, wherein the additives include a fire retardant, an antistatic agent, a dispersing agent and a coupling agent.
Abstract: The invention discloses a formula of multifunctional polymethylmethacrylate. The formula comprises polymethyl methacrylate and additives, wherein the additives include a fire retardant, an antistatic agent, a dispersing agent, a colorant and a coupling agent; the fire retardant is triphenyl phosphate; the antistatic agent is ethyoxyl lauro tyramine; the dispersing agent is triethylhexyl phosphoric acid; the colorant is palm oil acid diester; and the coupling agent is ammonia propyltriethoxysilane. Prepared polymethylmethacrylate has the characteristics of flame retardance, static electricity resistance, good internal dispersity, diversified colors, low production cost and the like.

10 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202324
202263
20217
202014
201931
201834