Triphenyl phosphate

About: Triphenyl phosphate is a research topic. Over the lifetime, 579 publications have been published within this topic receiving 6681 citations. The topic is also known as: phenyl phosphate & TPP.

Joint acute toxicity of tributyl phosphate and triphenyl phosphate to Daphnia magna

Abstract: In this study, the joint acute toxicity of tributyl phosphate (TBP) and triphenyl phosphate (TPP) was investigated using Daphnia magna as the test organism The median lethal concentrations for TBP and TPP at 24 and 48 h were 548 and 051 mg/L, 117 and 0089 mg/L, respectively When mixed at either equal concentration or various toxic unit ratios, TBP and TPP mixtures displayed an additive toxicity after both 24- and 48-h exposure This work suggests that the joint acute toxicity of TBP and TPP towards D magna can be predicted by calculating the toxic units of mixtures

Metabolic Mechanism of Aryl Phosphorus Flame Retardants by Cytochromes P450: A Combined Experimental and Computational Study on Triphenyl Phosphate

Abstract: Understanding metabolic mechanisms is critical and remains a difficult task in the risk assessment of emerging pollutants. Triphenyl phosphate (TPHP), a widely used aryl phosphorus flame retardant (aryl-PFR), has been frequently detected in the environment, and its major metabolite was considered as diphenyl phosphate (DPHP). However, knowledge of the mechanism for TPHP leading to DPHP and other metabolites is lacking. Our in vitro study shows that TPHP is metabolized into its diester metabolite DPHP and mono- and dihydroxylated metabolites by cytochromes P450 (CYP) in human liver microsomes, while CYP1A2 and CYP2E1 isoforms are mainly involved in such processes. Molecular docking gives the conformation for TPHP binding with the active species Compound I (an iron IV-oxo heme cation radical) in specific CYP isoforms, showing that the aromatic ring of TPHP is likely to undergo metabolism. Quantum chemical calculations have shown that the dominant reaction channel is the O-addition of Compound I onto the aro...

Investigations of Triphenyl Phosphate and Bis-(2-ethylhexyl) Phosphate Self-Assembled Films on Iron Surface Using Electrochemical Methods, Fourier Transform Infrared Spectroscopy, and Molecular Simulations

Abstract: The protection behaviors of two new phosphate self-assembled films, triphenyl phosphate (TPP) and bis-(2-ethylhexyl) phosphate (BEP), against the corrosion of iron in 0.5 M H2SO4 were investigated using the electrochemical impedance spectroscopy (EIS), polarization curves, Fourier transform infrared (FT−IR) spectroscopy, and molecular simulations. The polarization curves showed a decrease in corrosion current density for the electrode covered with phosphates. Impedance spectra demonstrated that the charge-transfer resistance (Rct) of the electrode covered with phosphate was greater than that of the naked iron electrode. Results show that TPP molecules can adsorb on the iron surface quickly in a short time and that the coverage (θ) of the film will get to the maximum in 4 h. Subsequently, the amount of TPP molecules on the iron surface remains constant, while θ of BEP on the iron surface increases with the immersion time in 24 h. FT−IR spectroscopy was applied for the surface analysis and confirmed the ads...