Topic
Triphenyl phosphate
About: Triphenyl phosphate is a research topic. Over the lifetime, 579 publications have been published within this topic receiving 6681 citations. The topic is also known as: phenyl phosphate & TPP.
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TL;DR: In this paper, the impurity effect on thermodynamic stability of the glacial phase, an apparently amorphous metastable phase observed in triphenyl phosphite (TPP), was investigated.
2 citations
20 Nov 2018-Journal of Environmental Science and Health Part C-environmental Carcinogenesis & Ecotoxicology Reviews
TL;DR: In silico simulations, a proton shuttle pathway for aryl hydroxylation of TPHP and P = O bond-assisted H-transfer mechanisms (rather than nonenzymatic hydrolysis) that lead to O-dealkylation/dearylations of phosphotriesters are discovered.
Abstract: The metabolic fate and toxicokinetics of organic phosphorus flame retardants catalyzed by cytochrome P450 enzymes (CYPs) are here investigated by in silico simulations, leveraging an active center model to mimic the CYPs, triphenyl phosphate (TPHP), tris(2-butoxyethyl) phosphate and tris(1,3-dichloro-2-propyl) phosphate as substrates. Our calculations elucidated key main pathways and predicted products, which were corroborated by current in vitro data. Results showed that alkyl OPFRs are eliminated faster than aryl and halogenated alkyl-substituted OPFRs. In addition, we discovered a proton shuttle pathway for aryl hydroxylation of TPHP and P = O bond-assisted H-transfer mechanisms (rather than nonenzymatic hydrolysis) that lead to O-dealkylation/dearylation of phosphotriesters.
2 citations
TL;DR: In this article , a real-time sensing strategy for triphenyl phosphate (TPHP) with an extremely serious biotoxicity is developed, where a UV-induced chemiluminescence (CL) sensing platform with potassium monopersulfate (PMS) as the source of reactive oxygen species (ROS) is established.
2 citations
Journal Article•
2 citations
TL;DR: In this paper , the root uptake pathways and cell wall accumulation mechanisms of organophosphate esters in wheat roots were elucidated, and it was shown that the symplast is the major pathway for uptake of both tris(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPHP), while the hydrophobic TPE was mainly stored in the root cell wall.
Abstract: The behavior of organophosphate esters (OPEs) in plants has drawn considerable attention because of their adverse effects to biota. However, the root uptake pathways and cell wall accumulation mechanisms of OPEs in plants are still unclear. In this study, the uptake pathways, subcellular distribution, and accumulation mechanisms of OPEs in wheat roots were elucidated. The results demonstrated that the symplast is the major pathway for uptake of both tris(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPHP) in wheat roots. Inhibitor experiments showed that the transmembrane transport of OPEs is a passive uptake process, and aquaporins and carrier proteins contribute to the uptake of OPEs. More than 69% of TCEP was accumulated in cell sap due to its high hydrophilicity, while the hydrophobic TPHP was mainly stored in the root cell wall. The sorption affinity of TPHP decreased gradually following the sequential fractionation of wheat roots, which confirmed the significant contribution to TPHP sorption on wheat roots. A significant positive correlation between the sorption affinity values and the percentage of aromatic carbon was observed (r2 = 0.856, p < 0.01), indicating that the accumulation of hydrophobic OPEs in roots does not just depend on lipids alone, but the aromatic moieties of lignin in the cell wall also contribute to OPE accumulation.
2 citations