Topic
Triterpene
About: Triterpene is a research topic. Over the lifetime, 4180 publications have been published within this topic receiving 81137 citations. The topic is also known as: triterpenes.
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TL;DR: The potential antidiabetic activity of ethyl acetate extract of the leaves of Lagerstroemia speciosa was investigated by α‐amylase and α‐glucosidase inhibition assay and the kinetics of inhibition of corosolic acid was discussed.
Abstract: The potential antidiabetic activity of ethyl acetate extract of the leaves of Lagerstroemia speciosa (LSL) was investigated by alpha-amylase and alpha-glucosidase inhibition assay. Six pentacyclic triterpenes (oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, corosolic acid and 23-hydroxyursolic acid) were isolated from LSL. Their structures were determined by spectroscopic analysis and their alpha-glycosidase and alpha-amylase inhibitory activities were investigated. They exhibited no or weak inhibitory activity against alpha-amylase and middle alpha-glucosidase inhibitory activities. Corosolic acid, which shows best bioactivity against alpha-glucosidase (IC(50) = 3.53 mu g/mL), contributes most to the alpha-glucosidase inhibitory activity of EtOAc extract. The kinetics of inhibition of corosolic acid was also discussed. Results from this study might provide the scientific evidence for LSL for the treatment of diabetes in traditional medicine. Copyright (C) 2008 John Wiley & Sons, Ltd.
186 citations
TL;DR: Both bidesmosides and derived monodesmosides showed little or no antifungal activity, whereas a comparatively higher degree of hemolytic activity could be determined for monodesMosides.
Abstract: At least 16 saponins were detected in the seeds of Chenopodium quinoa. The 5 previously isolated major saponins, 3-O-beta-D-glucuronopyranosyl oleanolic acid 28-O-beta-D-glucopyranosyl ester, 3-O-alpha-L-arabinopyranosyl hederagenin 28-O-beta-D-glucopyranosyl ester, 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl hederagenin 28-O-beta-D-glucopyranosyl ester, 3-O-alpha-L-arabinopyranosyl phytolaccagenic acid 28-O-beta-D-glucopyranosyl ester, 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl phytolaccagenic acid 28-O-beta-D-glucopyranosyl ester, and the new saponin 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl phytolaccagenic acid were isolated and characterized using mainly NMR spectroscopy, mass spectrometry, and chemical methods. The antifungal activity against Candida albicans and hemolytic activity on erythrocytes of these compounds and derived monodesmosides were evaluated. Both bidesmosides and derived monodesmosides showed little or no antifungal activity, whereas a comparatively higher degree of hemolytic activity could be determined for monodesmosides.
184 citations
TL;DR: In this paper, a new OSC gene (named as PNA) was expressed in a lanosterol synthase deficient (erg7) Saccharomyces cerevisiae strain GIL77.
183 citations
TL;DR: The recent knowledge of squalene biochemistry, its molecular properties, and its physiological effects are summarized and applications in nutrition, pharmacy, and medicine are discussed.
Abstract: Squalene is a natural triterpene and an important intermediate of sterol and hopanoid biosynthesis in various types of cell from bacteria to human. Synthesis and further conversion of squalene are key steps in the metabolism of sterols and related components. Here we summarize the recent knowledge of squalene biochemistry, its molecular properties, and its physiological effects. We compare squalene biosynthetic pathways in different cell types and describe biotechnological strategies to isolate this lipid. Finally, applications of squalene in nutrition, pharmacy, and medicine are discussed.
182 citations
TL;DR: The chemical structure and sources of squalene, a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery, are presented and the physicochemical and biological properties ofSqualene-containing emulsion products are evaluated in the context of paretteral formulations.
Abstract: Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.
180 citations