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Tumor progression

About: Tumor progression is a(n) research topic. Over the lifetime, 32665 publication(s) have been published within this topic receiving 1542603 citation(s). more


Open accessJournal Article
Abstract: MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein- coding genes involved in cancer. more

Topics: microRNA (52%), Carcinogenesis (51%), Epigenetics (51%) more

6,306 Citations

Journal ArticleDOI: 10.1126/SCIENCE.959840
Peter C. Nowell1Institutions (1)
01 Oct 1976-Science
Abstract: It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic variability within the original clone allowing sequential selection of more aggressive sublines. Tumor cell populations are apparently more genetically unstable than normal cells, perhaps from activation of specific gene loci in the neoplasm, continued presence of carcinogen, or even nutritional deficiencies within the tumor. The acquired genetic insta0ility and associated selection process, most readily recognized cytogenetically, results in advanced human malignancies being highly individual karyotypically and biologically. Hence, each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment. More research should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer. more

5,851 Citations

Journal ArticleDOI: 10.1126/SCIENCE.1203486
25 Mar 2011-Science
Abstract: Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are more fit to survive in an immunocompetent host or by establishing conditions within the tumor microenvironment that facilitate tumor outgrowth. Here, we discuss a unifying conceptual framework called "cancer immunoediting," which integrates the immune system's dual host-protective and tumor-promoting roles. more

Topics: Immunoediting (59%), Tumor progression (56%), Tumor microenvironment (53%) more

4,153 Citations

Open accessJournal ArticleDOI: 10.1038/NM.3394
Daniela F. Quail1, Johanna A. Joyce1Institutions (1)
01 Nov 2013-Nature Medicine
Abstract: Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects. more

Topics: Tumor progression (58%), Tumor microenvironment (56%), Stromal cell (55%) more

3,971 Citations

Journal ArticleDOI: 10.1056/NEJMOA040766
Abstract: Metastatic breast cancer (MBC) is considered incurable; therefore, palliative treatment is the only option. The biologic heterogeneity of the disease is reflected in its somewhat unpredictable clinical behavior. The presence of circulating tumor cells (CTCs) in patients with MBC about to start a new line of treatment has been shown to predict progression-free and overall survival. This prognostic value is independent of the line of therapy (eg, first or second line). Moreover, a multivariate analysis has shown the prognostic value of CTCs to be superior to that of site of metastasis, type of therapy, and length of time to recurrence after definitive primary surgery. These data suggest that the presence of CTCs may be used to modify the staging system for advanced disease. Larger studies are needed to confirm these data and evaluate the use of CTC detection in monitoring treatment and furthering our understanding of breast cancer biology when combined with other diagnostic technologies. more

Topics: Circulating tumor cell (65%), Breast cancer (59%), Metastatic breast cancer (57%) more

3,911 Citations

No. of papers in the topic in previous years

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Topic's top 5 most impactful authors

Domenico Ribatti

47 papers, 1.8K citations

Meenhard Herlyn

29 papers, 2.4K citations

Jia Fan

19 papers, 1.1K citations

Wataru Yasui

17 papers, 695 citations

Israel Vlodavsky

16 papers, 1.1K citations

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