Topic
Twin-to-twin transfusion syndrome
About: Twin-to-twin transfusion syndrome is a research topic. Over the lifetime, 661 publications have been published within this topic receiving 16047 citations. The topic is also known as: TTTS & Fetal blood loss from fetal hemorrhage into co-twin.
Papers published on a yearly basis
Papers
More filters
TL;DR: Staging of TT TS using the proposed criteria has prognostic significance and may allow comparison of outcome data of TTTS with different treatment modalities.
Abstract: Objective The purpose of this study was to evaluate the prognostic value of sonographic and clinical parameters to develop a staging classification of twin-twin transfusion syndrome (TTTS). Study design Severe TTTS was defined as the presence of polyhydramnios (maximum vertical pocket of > or = 8 cm) and oligohydramnios (maximum vertical pocket of Results A total of 80 of 108 referred patients met criteria for surgery, but only 65 were treated surgically: 48 with LPCV and 17 with umbilical cord ligation. Complete Doppler data were obtainable in 41 of 48 LPCV patients. Survival rates by stage for one or two fetuses were statistically different (chi-squared analysis = 12.9, df = 6, p = 0.044). Neither percent size discordance nor gestational age at diagnosis were predictive of outcome. Conclusion Staging of TTTS using the proposed criteria has prognostic significance. This staging system may allow comparison of outcome data of TTTS with different treatment modalities.
1,212 citations
TL;DR: Endoscopic laser coagulation of anastomoses is a more effective first-line treatment than serial amnioreduction for severe twin-to-twin transfusion syndrome diagnosed before 26 weeks of gestation.
Abstract: Background Monochorionic twin pregnancies complicated by severe twin-to-twin transfusion syndrome at midgestation can be treated by either serial amnioreduction (removal of large volumes of amniotic fluid) or selective fetoscopic laser coagulation of the communicating vessels on the chorionic plate. We conducted a randomized trial to compare the efficacy and safety of these two treatments. Methods Pregnant women with severe twin-to-twin transfusion syndrome before 26 weeks of gestation were randomly assigned to laser therapy or amnioreduction. We assessed perinatal survival of at least one twin (a prespecified primary outcome), survival of at least one twin at six months of age, and survival without neurologic complications at six months of age on the basis of the number of pregnancies or the number of fetuses or infants, as appropriate. Results The study was concluded early, after 72 women had been assigned to the laser group and 70 to the amnioreduction group, because a planned interim analysis demonstr...
1,083 citations
TL;DR: In an ultrasound screening study for measurement of fetal nuchal translucency thickness there were 102 monochorionic and 365 dichorionic twin pregnancies and the proportion of pregnancies with a birthweight discordancy of more than 25% was similar in the two groups.
566 citations
TL;DR: Most losses were at 24 weeks or less, and TTTS was the most important cause of death, and the risk of intrauterine demise appears to be small after 32 weeks.
461 citations
355 citations