Ultraviolet light

About: Ultraviolet light is a research topic. Over the lifetime, 49494 publications have been published within this topic receiving 843151 citations.

Ultraviolet B Regulation of Transcription Factor Families: Roles of Nuclear Factor-kappa B (NF-κB) and Activator Protein-1 (AP-1) in UVB-Induced Skin Carcinogenesis

Abstract: Prolonged and repeated exposure of the skin to ultraviolet light (UV) leads not only to aging of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage of cells induced by ultraviolet B (UVB) light both at the DNA level and molecular level initiates the activation of transcription factor pathways, which in turn regulate the expression of a number of genes termed the “UV response genes”. Two such transcription factor families that are activated in this way are those of the nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) families. These two transcription factor families have been identified to be involved in the processes of cell proliferation, cell differentiation and cell survival and therefore play important roles in tumorigenesis. The study of these two transcription factor pathways and the cross-talk between them in response to UVB exposure may help with the development of new chemopreventive strategies for the prevention of UVB-induced skin carcinogenesis.

Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

Abstract: Ro/SS-A antibodies are found in a number of human autoimmune disorders including Sjogren's syndrome and several systemic lupus erythematosus-related disorders. These heterogeneous autoantibodies are known to recognize several distinct cellular antigens. With synthetic oligonucleotides corresponding to amino acid sequence information we have isolated a full-length cDNA clone which encodes a human Ro ribonucleoprotein autoantigen. The 1,890-base pair clone contains an open reading frame that encodes a 417-amino acid, 48-kD polypeptide that migrates aberrantly at 60 kD by SDS-PAGE. Rabbit antibodies raised against this protein's recently described amino-terminal epitope react with a previously identified 52-kD human Ro protein and immunoprecipitate the human cytoplasmic RNAs. Ultraviolet light cross-linking studies suggest that this Ro protein binds each of the four major human cytoplasmic RNAs. The deduced amino acid sequence is 63% homologous to an Onchocerca volvulus antigen. Southern filter hybridization analysis indicates that this gene is not highly polymorphic and exists as a single copy in the human genome. Chromosomal localization studies place this gene on the short arm of chromosome 19 near the gene encoding the low density lipoprotein receptor.

Fluorescent tube with light emitting diodes

Abstract: A fluorescent tube is constituted by a fluorescent tubular body having a transparent glass tube coated with a fluorescent layer containing a fluorescent material on its inner surface, and an ultraviolet LED substrate inserted in the fluorescent tubular body and having an equal length to the fluorescent tubular body. The ultraviolet LED substrate has twenty-four ultraviolet light emitting devices each having a long life, and the left end of the ultraviolet LED substrate is connected with lead wires through which electric power is supplied. Accordingly, when ultraviolet rays are emitted from the twenty-four ultraviolet light emitting devices, the fluorescent layer emits light in its own fluorescent color, the fluorescent tubular body as a whole emits light and the surroundings are illuminated with the light. Hence, the fluorescent tube can be used for illumination. Alternatively, the fluorescent tubular body may be formed by a transparent silicone rubber which can be bent into any desired shape.

System and method for computer automated manufacturing using fluent material

Abstract: A system and method for constructing a three-dimensional object (10) from a design created on a CAD machine (14) is disclosed which includes a support (B) which may be indexed along two coordinate axes (X, Y) and a movable dispensing head (A) which indexes along a Z-axis. A fluent material (54) is dispensed or extruded from head (A) and as it is dispensed, the fluent material is subjected to a treatment by treatment sources (D) which cause the fluent material to transform into a fixed solidified state in the form of a three-dimensional object. Fluent material (54) may be a polymeric material which is solidified by an energy beam of ultraviolet light (56) upon dispensing. A shield (E) is provided to shield the dispensing head (A) and strand of material (54) so that the material is treated at the proper time and location to cause it to solidify properly to form the three-dimensional object. In accordance with the method, indexing takes place in desired steps so a dimensionally accurate object is formed.