Topic
Ultraviolet light
About: Ultraviolet light is a research topic. Over the lifetime, 49494 publications have been published within this topic receiving 843151 citations.
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TL;DR: The hypothesis that vitamin D produced in the skin from sunlight exposure may be associated with a protective action in ovarian cancer mortality is supported.
Abstract: Background In general, ovarian cancer incidence and mortality is higher in northern than southern latitudes. This ecologic study tests the hypothesis that vitamin D produced in the skin from sunlight exposure may be associated with a protective action in ovarian cancer mortality. Methods The association between average annual sunlight energy and age-specific ovarian cancer mortality rates in counties containing the 100 largest US cities was evaluated for 1979-1988. Simple linear regression was performed by decade using sunlight and ozone as independent variables and ovarian cancer rates as the dependent variable. Multiple regression was used to adjust for ozone and sulphur dioxide, since these atmospheric components may absorb ultraviolet light. Results Fatal ovarian cancer in these areas was inversely proportional to mean annual intensity of local sunlight in a univariate analysis (P = 0.0001), and in a regression adjusted for air pollution (P = 0.04). The association was also seen when restricted to 27 major urban areas of the US; however, probably due to a small sample size, this statistic did not reach significance. Conclusions This ecologic study supports the hypothesis that sunlight may be a protective factor for ovarian cancer mortality.
271 citations
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TL;DR: Treatment of de-epithelialized human corneas with riboflavin + long-wavelength ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly and catalyzes cross-linking reactions that require production of singlet oxygen ((1)O(2)), whose half-life is extended by D(2)O.
Abstract: Purpose.
Treatment of de-epithelialized human corneas with riboflavin (RF) + long-wavelength ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly. RFUVA treatment retards the progression of keratoconus, perhaps by cross-linking of collagen molecules, but exact molecular mechanisms remain unknown. Research described here tested possible chemical mechanisms of cross-linking.
271 citations
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TL;DR: The results show that rpoB/Rif(r) is an accurate and easy to employ detection system, and offers the advantage of allowing analysis of mutations occurring on the chromosome rather than on an extrachromosomal element.
271 citations
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TL;DR: Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying processes, usually in appropriate cancer types, and potentially retain patterns of activity and regulation operative in primary human cancers.
270 citations
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TL;DR: Gold nanoparticles strongly absorb both visible light and ultraviolet light to drive an oxidation reaction for a synthetic dye, as well as phenol degradation and selective oxidation of benzyl alcohol under UV light.
270 citations