Upstream activating sequence

TL;DR: The PAX7 gene is a member of the paired box containing gene family of transcription factors implicated in development of the skeletal muscle of the trunk and limbs as well as elements of the central nervous system and the molecular mechanisms involved in its expression are understood.

TL;DR: The binding sites of TFID, a species-dependent transcription factor, on the mouse ribosomal RNA gene (rDNA) have been analyzed by DNase I footprinting using partially purified TFID and the pattern of protection of the upstream sequence suggests that at least a part of the downstream binding does not require a specific DNA sequence there but rather is caused by protein-protein interaction involving TFID bound with the core sequence.

TL;DR: The complete exon structure of ITGA11, including the proximal promoter, was assembled into 30 exons and promoter sequence analysis in silico suggested the presence of multiple binding sites for transcription factors in the region upstream of the transcription start.

TL;DR: It is reported that CD40-dependent TRAF1 gene transcription in murine B cells is controlled by two enhancer regions that are located approximately 2 kb upstream of the transcription start site and the other lies in the intron between exons 5 and 6.

TL;DR: A novel yeast one-hybrid system which easily allows for the detection of mutations in the ligand-binding domain of the estrogen receptor and one of the mutants generated was a more potent activator of transcription and also appeared to have a higher affinity for [3H]estradiol in vivo than the wild type receptor.