Topic
Upstream activating sequence
About: Upstream activating sequence is a research topic. Over the lifetime, 1633 publications have been published within this topic receiving 100112 citations.
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Dissertation•
01 Jan 2001
5 citations
TL;DR: The results demonstrated that activator protein 1(AP-1) cis-element plays a crucial role in IRAK-M constitutive gene transcription, and highlights the importance of AP-1 in IRAk-M transcription, which offers more information on the role of IRAK -M in infectious and non-infectious diseases.
5 citations
TL;DR: It is suggested that the CUS-G0S 19-3 sequence was generated by recombination between a G0S19-2 gene and a member of a novel C US-associated gene family, which might promote the transcription of sequences with which it became associated.
Abstract: The murine gene, MIP1α, encodes a cytokine (macrophage inflammatory protein 1α) that inhibits the proliferation of bone marrow stem cells Two human homologs have been characterized, G0S19-1 and G0S19-2 Like MIP1α, these genes contain three exons, the first of which encodes a hydrophobic signal sequence The existence of a third human G0S19 gene, present in one in four individuals, has been predicted from restriction enzyme analyses This paper reports that a previously identified human genomic clone containing a G0S19 sequence (G0S19-3), corresponds to the third gene However, the first G0S19 exon is missing The sequence differs from those of G0S19-1 and G0S19-2 upstream of a point 31 nucleotides from the junction of the first intron with the second exon This upstream sequence contains a CpG island and is named "CpG island-containing upstream sequence," CUS Apart from the G0S19-3-associated copy found only in individuals with the third G0S19 gene, all individuals have one DNA species hybridi
5 citations
01 Jan 1988
TL;DR: Three avian nuclear proteins which bind to the Rous sarcoma virus long terminal repeat have been detected.
Abstract: Three avian nuclear proteins which bind to the Rous sarcoma virus long terminal repeat have been detected. Two of the proteins bind to sequences within the enhancer, and the third protein binds to a sequence spanning the enhancer and an upstream promoter region.
5 citations
TL;DR: RNAs originating from the 5'-flanking region of the chicken very-low-density apolipoprotein II (apoVLDLII) gene are investigated, finding that the low concentration of the upstream initiated transcripts is due both to low transcription levels and to low transcript stability.
5 citations