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Urea

About: Urea is a research topic. Over the lifetime, 21394 publications have been published within this topic receiving 382444 citations. The topic is also known as: carbamide & carbonic acid diamide.


Papers
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Journal ArticleDOI
TL;DR: In this paper, three Holstein crossbred dairy cows were randomly allocated to 3 treatments of rice straw (T1 = untreated rice straw; T2 = 5.5% urea-treated rice straw and 2.2% calcium hydroxide treated rice straw) according to a 3 × 3 Latin square design.

153 citations

Journal ArticleDOI
TL;DR: The biochemical and enzymatic fundamentals of ammonia toxicity and automatic regulation of urea formation from ammonia are presented and Ornithine-keto acid transaminase activity was found to be an important regulator of liver ornithine contents and further urea cycle activities.

153 citations

Journal ArticleDOI
TL;DR: This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.
Abstract: 1,3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate their structure−activity relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. For example, 1-(1-(cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (52) showed a 7-fold increase in potency, a 65-fold increase in Cmax, and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperidin-4-yl)urea (2). This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.

153 citations

Journal ArticleDOI
TL;DR: Interorgan trafficking of ammonia during acute and chronic liver failure is discussed and muscle takes up ammonia and plays a major role in (temporarily) detoxifying ammonia to glutamine, since glutamine synthesis from glutamate and ammonia is an important alternative pathway of ammonia detoxification.

153 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231,000
20221,982
2021433
2020502
2019589
2018557