Topic
Urea
About: Urea is a research topic. Over the lifetime, 21394 publications have been published within this topic receiving 382444 citations. The topic is also known as: carbamide & carbonic acid diamide.
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TL;DR: In this paper, three Holstein crossbred dairy cows were randomly allocated to 3 treatments of rice straw (T1 = untreated rice straw; T2 = 5.5% urea-treated rice straw and 2.2% calcium hydroxide treated rice straw) according to a 3 × 3 Latin square design.
153 citations
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TL;DR: The biochemical and enzymatic fundamentals of ammonia toxicity and automatic regulation of urea formation from ammonia are presented and Ornithine-keto acid transaminase activity was found to be an important regulator of liver ornithine contents and further urea cycle activities.
153 citations
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TL;DR: This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.
Abstract: 1,3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate their structure−activity relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. For example, 1-(1-(cyclopropanecarbonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (52) showed a 7-fold increase in potency, a 65-fold increase in Cmax, and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperidin-4-yl)urea (2). This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.
153 citations
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153 citations
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TL;DR: Interorgan trafficking of ammonia during acute and chronic liver failure is discussed and muscle takes up ammonia and plays a major role in (temporarily) detoxifying ammonia to glutamine, since glutamine synthesis from glutamate and ammonia is an important alternative pathway of ammonia detoxification.
153 citations