About: Urinary bladder is a research topic. Over the lifetime, 23176 publications have been published within this topic receiving 584688 citations. The topic is also known as: bladder.
Papers published on a yearly basis
TL;DR: These data from a large group of patients support the aggressive surgical management of invasive bladder cancer and suggest excellent long-term survival can be achieved with a low incidence of pelvic recurrence.
Abstract: PURPOSE: To evaluate our long-term experience with patients treated uniformly with radical cystectomy and pelvic lymph node dissection for invasive bladder cancer and to describe the association of the primary bladder tumor stage and regional lymph node status with clinical outcomes. PATIENTS AND METHODS: All patients undergoing radical cystectomy with bilateral pelvic iliac lymphadenectomy, with the intent to cure, for transitional-cell carcinoma of the bladder between July 1971 and December 1997, with or without adjuvant radiation or chemotherapy, were evaluated. The clinical course, pathologic characteristics, and long-term clinical outcomes were evaluated in this group of patients. RESULTS: A total of 1,054 patients (843 men [80%] and 211 women) with a median age of 66 years (range, 22 to 93 years) were uniformly treated. Median follow-up was 10.2 years (range, 0 to 28 years). There were 27 (2.5%) perioperative deaths, with a total of 292 (28%) early complications. Overall recurrence-free survival at ...
Charles University in Prague1, University of Regensburg2, First Faculty of Medicine, Charles University in Prague3, Imperial College London4, University of Hertfordshire5, Pierre-and-Marie-Curie University6, Autonomous University of Barcelona7, Netherlands Cancer Institute8, Medical University of Vienna9, European Association of Urology10, Medical University of Graz11
TL;DR: These abridged EAU guidelines present updated information on the diagnosis and treatment of NMIBC for incorporation into clinical practice and the stratification of patients into low-, intermediate-, and high-risk groups is pivotal to recommending adjuvant treatment.
TL;DR: BCG immunotherapy was beneficial in patients with carcinoma in situ and select patients with Ta, T1 bladder cancer, and patients had significantly longer worsening-free survival.
TL;DR: The organs found to be frequently and significantly involved by systemic sclerosis were the skin, gastrointestinal tract, lungs, kidneys, skeletal muscle and pericardium, and atrophy was usually a more prominent finding than was fibrosis in organs containing smooth muscle.
TL;DR: P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes and may have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder.
Abstract: Extracellular ATP is implicated in numerous sensory processes ranging from the response to pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively expressed on small diameter sensory neurons, supporting this hypothesis. Here we show that mice deficient in P2X3 lose the rapidly desensitizing ATP-induced currents in dorsal root ganglion neurons. P2X3 deficiency also causes a reduction in the sustained ATP-induced currents in nodose ganglion neurons. P2X3-null mice have reduced pain-related behaviour in response to injection of ATP and formalin. Significantly, P2X3-null mice exhibit a marked urinary bladder hyporeflexia, characterized by decreased voiding frequency and increased bladder capacity, but normal bladder pressures. Immunohistochemical studies localize P2X3 to nerve fibres innervating the urinary bladder of wild-type mice, and show that loss of P2X3 does not alter sensory neuron innervation density. Thus, P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes. Antagonists to P2X3 may therefore have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder.
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