scispace - formally typeset
Search or ask a question
Topic

Valency

About: Valency is a research topic. Over the lifetime, 1632 publications have been published within this topic receiving 26141 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Increasing valency and decreasing linker length, increases effective local concentration of the inhibitor and therefore, resulted in stronger inhibition of plasmin via statistical rebinding and aids in the design of multivalent inhibitors that can achieve desired enzyme inhibition by means of modulating valency
Abstract: There is an emerging interest in utilizing synthetic multivalent inhibitors that comprise of multiple inhibitor moieties linked on a common scaffold to achieve strong and selective enzyme inhibition. As multivalent inhibition is impacted by valency and linker length, in this study, we explore the effect of multivalent benzamidine inhibitors of varying valency and linker length on plasmin inhibition. Plasmin is an endogenous enzyme responsible for digesting fibrin present in blood clots. Monovalent plasmin(ogen) inhibitors are utilized clinically to treat hyperfibrinolysis‐associated bleeding events. Benzamidine is a reversible inhibitor that binds to plasmin's active site. Herein, multivalent benzamidine inhibitors of varying valencies (mono‐, bi‐ and tri‐valent) and linker lengths (∼1–12 nm) were synthesized to systematically study their effect on plasmin inhibition. Inhibition assays were performed using a plasmin substrate (S‐2251) to determine inhibition constants (Ki). Pentamidine (shortest bivalent) and Tri‐AMB (shortest trivalent) were the strongest inhibitors with Ki values of 2.1±0.8 and 3.9±1.7 μM, respectively. Overall, increasing valency and decreasing linker length, increases effective local concentration of the inhibitor and therefore, resulted in stronger inhibition of plasmin via statistical rebinding. This study aids in the design of multivalent inhibitors that can achieve desired enzyme inhibition by means of modulating valency and linker length.

1 citations

Journal ArticleDOI
TL;DR: This article used frame semantics theory to determine a verb's meaning based on its semantic context and frame-semantics, and obtained the verb valency pattern to add to a dictionary's morphological and grammatical information.
Abstract: The verb is one of the most perplexing features for learners of BIPA (Bahasa Indonesia bagi Penutur Asing “Indonesian for foreign speakers”). Indonesian verbs are particularly rich in affixes that correspond to their numerous senses. The learners find it challenging to use verbs with the appropriate affixes in a sentence structure. To function effectively as a learning tool, dictionaries must provide morphological and grammatical information. Frame semantics theory is used in this research to determine a verb’s meaning based on its semantic context and frame. The verb is described by identifying the grammatical constructions in which it participates, and by characterizing all of the obligatory and optional types of companions. By doing this, we can obtain the verb valency pattern to add to a dictionary’s morphological and grammatical information. This study aims to create entry models of affixed verbs with the valency pattern. The six transitive verbs for discussion comprise a variety of affixes with various senses: mempersembahkan “to present/dedicate”; membersihkan “to clean”; mencintai “to love”; memperlancar “to expedite”; memperbaiki “to fix”; and memberlakukan “to apply”. These entries serve as models for the BIPA learner’s dictionary.

1 citations

Book ChapterDOI
01 Jan 2001
TL;DR: In this article, the authors explain the valency and argument structure of the predicate and show that the argument structure can also be altered or rearranged without involving a change of valency.
Abstract: The purpose of this article is to explain the valency and argument structure of the predicate. The article begins with definitions of valency and argument structure. This then leads to illustration of a number of ways in which arguments are removed from, or added to, the argument structure, whereby changes in the valency of the basic predicate may be brought about. The article demonstrates that the argument structure can also be altered or rearranged without involving a change of valency. Also illustrated is how languages may keep the valency of the derived predicate from exceeding that of the basic predicate. The article addresses the question of whether or not identical coding of nominals – especially in the context of valency increasing – entails doubling of grammatical relations. Finally, a brief discussion of how valency-changing operations are handled or represented in current grammatical theories is provided.

1 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the relation between perceptual, cognitive, emotional processes, and linguistic experience within the observer framework and concluded that the ternion in question is a component of human expressivity constituting the semiotic space of the thymic category.
Abstract: The current study addresses the nature of the relation between perceptual, cognitive, emotional processes, and linguistic experience within the observer framework. As an extension of the already conducted investigations into the semiotics of the sensible, the conceptual triad SENSE : FEELING : EMOTION is introduced. The study argues that the ternion in question is a component of human expressivity constituting the semiotic space of the thymic category. The synergism of cognitive-semantic characteristics of the three concepts under study corresponds to the basic level of categorisation in modern English. More significantly, the aim of the analysis is to consider the valency models of the names of the conceptual triad SENSE : FEELING : EMOTION as well as their collocability potential. The present paper highlights that the structures of predicate valency of conceptual dependencies FEELING → SENSE (the valency index equals 0,38) outnumber the analogous structures FEELING → EMOTION (the valency index equals 0,24). The structures of object valency of the combinations FEELING → EMOTION (the valency index is 0,9) prevail over the combinations SENSE → FEELING (with the valency index of 0,1). The data obtained confirm the idea that the correlation between observer and observable is twofold: cognitive-perceptual correlation denotes the observer’s outward perspective, whereas cognitive-emotional correlation denotes the observer’s inward perspective.

1 citations


Network Information
Related Topics (5)
Phase transition
82.8K papers, 1.6M citations
69% related
Ground state
70K papers, 1.5M citations
68% related
Monolayer
47.3K papers, 1.5M citations
67% related
Band gap
86.8K papers, 2.2M citations
67% related
Ab initio
57.3K papers, 1.6M citations
67% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202377
2022190
202119
202029
201937
201829