Topic
Vanadate
About: Vanadate is a research topic. Over the lifetime, 4497 publications have been published within this topic receiving 120109 citations. The topic is also known as: vanadate.
Papers published on a yearly basis
Papers
More filters
TL;DR: It is demonstrated that vanadate induces p53 activation mainly through H2O2 generation, and this activation is required forVanadate-induced apoptosis, which was very weak in p53-deficient cells.
162 citations
TL;DR: The results suggest that dissociation of the V-ATPase complex in vivo is controlled both by the cellular environment and by the 100-kDa a-subunit isoform present in the complex.
160 citations
TL;DR: In this paper, the authors have shown that vanadium is a redox-sensitive element, which occurs in three oxidation states (+III, +IV and +V) in the environment.
160 citations
TL;DR: The findings demonstrate that vanadate stimulates glucose transport by an effect at a level distal to the insulin receptor, and induction of a post-receptor defect by prolonged exposure to insulin decreases the potency of a maximally effective concentration ofVanadate.
Abstract: Sodium vanadate has several insulin-like effects. To determine whether vanadate acts via the insulin receptor, I investigated the effect of vanadate on glucose transport (2-deoxyglucose uptake) in adipocytes that had been treated to decrease the number of insulin receptors. Trypsin (100 micrograms/ml) caused greater than 95% loss of 125I-insulin binding and rendered glucose transport resistant to both insulin and an anti-insulin-receptor antibody. However, vanadate caused an 8-fold increase in the transport rate [EC50 (concn. giving 50% of maximum effect) 0.2 mM] in both control and trypsin-treated cells, demonstrating that the insulin receptor does not have to be intact for vanadate to stimulate glucose transport. Insulin receptors were depleted by treatment of adipocytes with insulin (100 ng/ml) in the presence of Tris (which blocks receptor recycling). A 2 h treatment caused 60% loss of receptors, and a shift to the right in the dose-response curve for insulin stimulation of glucose transport (EC50 0.3 ng of insulin/ml in controls, 1.2 ng/ml in treated cells). The response to vanadate was again unaffected. Treatment with insulin for 4 h caused a 67% decrease in insulin binding and, in addition to the rightward shift in the insulin dose-response curve, a decrease in basal and maximal transport rates (which cannot be explained by decreased insulin receptor number). The EC50 of vanadate was again equal in control and treated cells, but glucose transport in the presence of a maximally effective concentration of vanadate (1 mM) was decreased. I conclude that the effect of vanadate on glucose transport is independent of the insulin receptor. Induction of a post-receptor defect (which may be a decrease in the total number of cellular glucose transporters) by prolonged exposure to insulin decreases the potency of a maximally effective concentration of vanadate. The findings demonstrate that vanadate stimulates glucose transport by an effect at a level distal to the insulin receptor.
160 citations
TL;DR: The paper explores the possibility of coupling vanadium pantaoxide into iron vanadate that improves optical properties and photocatalytic activity and prepares FeVO4/V2O5 nanocomposite via in-situ ultrasound-assisted procedure by using NH4F in one step.
160 citations