Topic
Vanadate
About: Vanadate is a research topic. Over the lifetime, 4497 publications have been published within this topic receiving 120109 citations. The topic is also known as: vanadate.
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TL;DR: Observations are consistent with the hypothesis that protein kinase C functions to attenuate the stimulation of Na+/H+ exchange by polypeptide growth factors.
Abstract: Addition of polypeptide growth factors to cultured cells results in a rapid stimulation of Na+/H+ exchange, which leads to cytoplasmic alkalinization. We studied the effects of the potent tumor promoter phorbol 12-myristate 13-acetate (PMA) on the Na+/H+ exchange system of A431 cells. Stimulation of Na+/H+ exchange by epidermal growth factor (EGF) and serum as well as by vanadate ions is strongly inhibited after treatment of cells with nanomolar concentrations of PMA. Phorbol esters that have no activity as tumor promoters also do not modulate the activation of Na+/H+ exchange. By contrast, the stimulation of Na+/H+ exchange that is produced upon exposure of cells to hypertonic solution is only slightly inhibited by PMA treatment, indicating that PMA treatment does not directly block the activity of the Na+/H+ antiporter. Furthermore, incubation of cells with PMA causes a weak stimulation of Na+/H+ exchange, although this effect is mostly observed at relatively high PMA concentrations and appears to require external Ca2+. The inhibition BY PMA of EGF-promoted Na+/H+ exchange is not due to inhibition of EGF-binding to the EGF receptor. Since PMA activates protein kinase C, our observations are consistent with the hypothesis that protein kinase C functions to attenuate the stimulation of Na+/H+ exchange by polypeptide growth factors.
73 citations
TL;DR: It is proposed that SSAO activity and vanadate potently mimic insulin effects in adipose cells and exert an anti-diabetic action in an animal model of type 1 diabetes mellitus.
73 citations
TL;DR: The results show that, like Pi, vanadate accelerates the turnover rate of cross-bridges, but is effective at about 1/500 the concentration required for the Pi effect.
73 citations
TL;DR: Data showed that the neurosecretory vesicles possess a membrane H+-translocating system and prompted the study of Mg2+-dependent ATPase activities in the vesicle fractions.
73 citations
TL;DR: In this paper, the IR and Raman spectra of Mg orthovanadate Mg3(VO4)2, Mg pyrovanadate mg2V2O7 and Mg metavanadate nv2O6 powders are reported, described and discussed on the basis of the crystal structures of these phases and of the optical activity of the fundamental vibrational modes predicted with the use of the correlation method.
Abstract: The IR and Raman spectra of Mg orthovanadate Mg3(VO4)2, Mg pyrovanadate Mg2V2O7 and Mg metavanadate MgV2O6 powders are reported, described and discussed on the basis of the crystal structures of these phases and of the optical activity of the fundamental vibrational modes predicted with the use of the correlation method. The IR-active combinations are also discussed. The structural and vibrational features of these compounds are discussed in relation to those of other V-based oxidic catalytic materials.
73 citations