Verrucous carcinoma

About: Verrucous carcinoma is a research topic. Over the lifetime, 1432 publications have been published within this topic receiving 25022 citations. The topic is also known as: Warty carcinoma & verrucous carcinoma NOS (morphologic abnormality).

Histological typing of cancer and precancer of the oral mucosa

Abstract: Histological Classification of Cancer and Precancer of the Oral Mucosa.- Definitions and Explanatory Notes.- Carcinomas.- Benign Lesions Capable of Microscopically Resembling Oral Squamous Cell Carcinoma and Oral Verrucous Carcinoma.- Precancerous Lesions (Clinical Classification).- Precancerous Lesions (Histological Classification).- Benign Lesions Capable of Resembling Oral Precancerous Lesions.- Precancerous Conditions.- TNM Classification of Lip and Oral Cavity Carcinomas.- Illustrations.

Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta-analysis, 1982-1997

Abstract: Objective. Human papillomavirus (HPV) infection is a significant risk factor for uterine cervical carcinoma. However, the role of HPV infection in oral squamous cell carcinoma (OSCC) is less well defined. To determine the significance of the relationship of this virus in the progressive development of oral cancer, we estimated the risk of HPV detection in normal oral mucosa, precancerous oral tissue, and oral carcinoma using meta-analysis. Study design. Case reports and clinical series published in English-language journals were retrieved by searching MEDLINE (January 1980-August 1998). Review articles were also examined to identify additional studies. Studies that used biochemical, immunologic, microscopic, or molecular analyses to detect HPV in tissue or cells derived from normal oral mucosa (n = 25), benign leukoplakia (n = 21), intraepithelial neoplasia (ie, dysplasia and carcinoma in situ; n = 27), and oral cancer (n = 94) were included in the meta-analysis. Information on sample size, age, sex, method of tissue preservation (ie, fresh, frozen, paraffin-embedded), assay, primer amplification region (early, late), high-risk versus low-risk genotype, and use of tobacco or alcohol was abstracted by one author (C.S.M.). Results. Data from 94 reports that analyzed 4680 samples were included in the meta-analysis. Analyses made by means of a random-effects model with and without adjustments for assay sensitivity showed increased probability of HPV detection in tissue with precancerous and cancerous features compared with normal mucosa. The likelihood of detecting HPV in normal oral mucosa (10.0%; 95% confidence interval [CI], 6.1%-14.6%) was significantly less than of detecting benign leukoplakia (22.2%; 95% CI, 15.7%-29.9%), intraepithelial neoplasia (26.2%; 95% CI, 19.6%-33.6%), verrucous carcinoma (29.5%; 95% CI, 23%-36.8%), and OSCC (46.5%; 95% CI, 37.6%-55.5%). Adjustment of findings for differences in assay sensitivity indicated that these estimates may be conservative. Overall, HPV was between 2 and 3 times more likely to be detected in precancerous oral mucosa and 4.7 times more likely to be detected in oral carcinoma than in normal mucosa. The pooled odds ratio for the subset of studies directly comparing the prevalence of HPV in normal mucosa and OSCC was 5.37, confirming the trend observed in the overall sample. The probability of detecting high-risk HPVs in OSCCs was 2.8 times greater than that of low-risk HPVs. Conclusion. This meta-analysis indicates that HPV is detected with increased frequency in oral dysplastic and carcinomatous epithelium in comparison with normal oral mucosa. The findings provide further quantitative evidence that oral infection with HPV, particularly with high-risk genotypes, is a significant independent risk factor for OSCC. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:622-35)

Verrucous carcinoma. Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia.

Abstract: Verrucous carcinoma, a distinctive variant of epidermoid carcinoma, was found in the oral cavity (77 cases), larynx (12 cases), nasal fossa (4 cases), glans penis (8 cases), vulva (1 case), vagina (1 case), scrotum (1 case). A relationship between the use of chewing tobacco and oral cavity lesions was evident in this indigent, predominantly rural patient group. Locally aggressive behavior with bone invasion occurred in 15 instances. Lymph node metastases were not found except in 4 patients treated by radiation, apparently as a result of alteration of the biologic character of the lesion. Radiation therapy (17 patients) failed to control the lesion in all instances. The response to surgical excision (88 patients) was excellent.

Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis.

Abstract: To clarify the role of human papillomavirus (HPV) in penile cancer we evaluated the prevalence of HPV DNA in different histological subtypes of penile carcinoma, dysplasia, and condyloma using a novel, sensitive SPF10 HPV polymerase chain reaction assay and a novel genotyping line probe assay, allowing simultaneous identification of 25 different HPV types. Formalin-fixed, paraffin-embedded tissue samples were collected from the United States and Paraguay. HPV DNA was detected in 42% cases of penile carcinoma, 90% cases of dysplasia, and 100% cases of condyloma. There were significant differences in HPV prevalence in different histological cancer subtypes. Although keratinizing squamous cell carcinoma and verrucous carcinoma were positive for HPV DNA in only 34.9 and 33.3% of cases, respectively, HPV DNA was detected in 80% of basaloid and 100% of warty tumor subtypes. There was no significant difference in HPV prevalence between cases from Paraguay and the United States. In conclusion, the overall prevalence of HPV DNA in penile carcinoma (42%) is lower than that in cervical carcinoma (∼100%) and similar to vulvar carcinoma (∼50%). In addition, specific histological subtypes of penile cancer—basaloid and warty—are consistently associated with HPV, however, only a subset of keratinizing and verrucous penile carcinomas is positive for HPV DNA, and thus these two tumor groups seem to develop along different pathogenetic pathways.