Topic
Virus
About: Virus is a research topic. Over the lifetime, 136914 publications have been published within this topic receiving 5209107 citations. The topic is also known as: infectious agent & viruses.
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TL;DR: It is reported that virus attachment to DAF on the apical cell surface activates Abl kinase, triggering Rac-dependent actin rearrangements that permit virus movement to the tight junction.
529 citations
TL;DR: The isolation of Nipah virus from the Island flying-fox corroborates the serological evidence that it is one of the natural hosts of the virus.
529 citations
TL;DR: It is shown that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes, and nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses.
529 citations
TL;DR: Genotypic and potential phenotypic differences imply that the isolates causing this outbreak form two separate subclades, and diversity among isolates implies that the H7N9 virus has evolved into at least two different lineages.
529 citations
TL;DR: It is shown that ferrets and domestic cats are susceptible to infection by SARS coronavirus (SCV) and that they can efficiently transmit the virus to previously uninfected animals that are housed with them.
Abstract: There is now a choice of animal models for testing therapies against the human virus. The reservoir of the coronavirus isolated from patients with severe acute respiratory syndrome (SARS)1,2 is still unknown, but is suspected to have been a wild animal species. Here we show that ferrets (Mustela furo) and domestic cats (Felis domesticus) are susceptible to infection by SARS coronavirus (SCV) and that they can efficiently transmit the virus to previously uninfected animals that are housed with them. The observation that these two distantly related carnivores can so easily be infected with the virus indicates that the reservoir for this pathogen may involve a range of animal species.
528 citations