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Showing papers on "White Muscle Disease published in 1960"


Journal ArticleDOI
TL;DR: Evidence suggests an essential role for selenium in supporting growth of lambs as compared to untreated controls and massive doses of Vit.
Abstract: Summary1) Selenium, given pre-natally per os to ewes or post-natally by injection to lambs, prevented WMD and resulted in increased growth of lambs as compared to untreated controls. 2) Growth response to selenium fed pre-natally was greater than that to selenium injected post-natally. 3) Massive doses of Vit. E at birth protected lambs from WMD, but did not result in improved growth. 4) Evidence suggests an essential role for selenium in supporting growth of lambs.

35 citations



Journal ArticleDOI
TL;DR: Foals show in addition to muscle degeneration a typical yellow fat disease as it occurs in vitamin E deficient rats and in mink as a natural disease.
Abstract: Extract At least three types of natural disease characterized by muscle degeneration have been recorded in the horse. These are the well-known paralytic myoglobinuria, polymyositis, and a myositis of the lingual and maxillary muscles. The first is apparently world-wide, whereas the others have been recorded in few countries. Polymyositis (a term used in Scandinavian countries) and its relationship to a muscle degeneration in foals in New Zealand has been referred to by Hartley and Dodd (1957). Both conditions occur in suckling foals and are similar, if not identical, to one another and to white muscle disease in calves and lambs. Foals, however, show in addition to muscle degeneration a typical yellow fat disease as it occurs in vitamin E deficient rats and in mink as a natural disease.

24 citations


Journal ArticleDOI
19 Mar 1960-Nature
TL;DR: The suggested direct relationship between urinary selenium concentrations and the prevalence of dental caries in American children is not substantiated by an investigation in New Zealand, but the marked improvement in health, weight gain, and reduction of muscular dystrophy in sheep by dosing withSelenium suggests there is a minimum level of available selenum in many areas of New Zealand.
Abstract: THE suggested direct relationship between urinary selenium concentrations and the prevalence of dental caries in American children1,2 is not substantiated by an investigation in New Zealand. Until recently, studies on the physiological effects of selenium have been concerned with its toxicity. Later evidence sxiggests that for some animals, and at certain levels, the element may be classified as essential3. Although selenium has not been demonstrated to be essential in man, its suspected role in electron transport may suggest a possible modification of the calcified structures. In New Zealand, the marked improvement in health, weight gain, and reduction of muscular dystrophy in sheep (‘white muscle disease’) by dosing with selenium4, suggests there is a minimum level of available selenium in many areas of New Zealand. This evidence warranted an investigation of the supposed selenium–caries relationship.

20 citations



Journal ArticleDOI
TL;DR: Further observations on the incidence of, and factors connected with, white muscle disease in lambs are described.
Abstract: Extract This paper describes further observations on the incidence of, and factors connected with, white muscle disease in lambs. It supplements previous papers by Hartley (1953) and Hartley and Dodd (1957).

13 citations



Journal ArticleDOI
TL;DR: Suitable conditions for assay for 5-nucleotidase activity in lamb skeletal muscle tissue are described and the activity of this enzyme was significantly greater in tissues from lambs affected by white muscle disease than in tissue from normal lambs.
Abstract: SummarySuitable conditions for assay for 5-nucleotidase activity in lamb skeletal muscle tissue are described. The activity of this enzyme was significantly greater in tissues from lambs affected by white muscle disease than in tissues from normal lambs.The authors acknowledge efficient technical assistance of Pauline Fleetwood.

5 citations