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White Muscle Disease
About: White Muscle Disease is a research topic. Over the lifetime, 165 publications have been published within this topic receiving 2812 citations.
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TL;DR: It is shown that abnormalities develop after a few weeks in the electrocardiograms of both rats and lambs fed dystrophogenic diets in experimental conditions and these abnormalities can be prevented by the administration of adequate selenium or tocopherol.
Abstract: FRASER and I1,2 have previously shown that abnormalities develop after a few weeks in the electrocardiograms of both rats and lambs fed dystrophogenic diets in experimental conditions. These abnormalities can be prevented by the administration of adequate selenium or tocopherol. Without such supplementation the rats die with hepatic necrosis, while the lambs develop lesions typical of white muscle disease (WMD) which in these experimental conditions always proves fatal
11 citations
11 citations
TL;DR: It appears that rapid accumulation of calcium into the damaged cells possibly interferes with the mitochondrial activity as mitochondria bind excessive calcium, their capacity to respire and phosphorylate is depressed thus causing myocardial necrosis.
Abstract: White muscle disease (WMD), a selenium-responsive cardiac myopathy in neonatal lambs has been described from southern Iran. 15 lambs in terminal condition were referred to our lab. All the lambs were observed with the affected hearts. The lambs examined were between the postnatal ages of 1 week and 3 months. Gross changes included chalky-white appearance of entire endocardium of right ventricle and subendocardial plaques in the interventricular septum and left ventricular wall. Histologically the affected myofibrils showed swelling, acidophilia, fragmentation, segmental and patchy myonecrosis, round muscle cell nuclei, loss of sarcoplasm and sarcolemmal collapse. Purkinje fibers were relatively unaffected. Histochemical studies including Von Kossa and other stains indicated marked deposition of calcium salts in the cytoplasm of the damaged myofibrils. Calcium salts appeared as uniform, fine granules in relation to individual fiber striations. It appears that rapid accumulation of calcium into the damaged cells possibly interferes with the mitochondrial activity. As mitochondria bind excessive calcium, their capacity to respire and phosphorylate is depressed thus causing myocardial necrosis. The cardiac myopathy noted in our investigation is probably due to selenium deficiency in the soil of southern Iran. When selenium was given, it resulted in the fast recovery of the affected neonatal lambs. Moreover, no further cases of this disease (WMD) were reported after such treatments.
10 citations
TL;DR: Protection from the disease was given by selenium when it was administered regularly as an oral drench, or incorporated into an intraruminal heavy pellet placed in the rumen at weaning.
Abstract: Typical white muscle disease has been induced in lambs that were normal at weaning but thereafter fed natural dystrophogenic fodder for 2-4 months. Protection from the disease was given by selenium when it was administered regularly as an oral drench, or incorporated into an intraruminal heavy pellet placed in the rumen at weaning.
10 citations