Showing papers on "Wieland–Miescher ketone published in 2016"
01 Jul 2016
TL;DR: The first total synthesis of isospongian diterpenoid (+/-)-polyrhaphin D has been accomplished in 9 steps with 19% overall yield starting from the Wieland-Miescher ketone derivative as mentioned in this paper.
Abstract: The first total synthesis of isospongian diterpenoid (+/-)-polyrhaphin D has been accomplished in 9 steps with 19% overall yield starting from the Wieland-Miescher ketone derivative. The key features of our synthesis include a sequential reduc-tion/Michael addition/aldol condenzation to assemble the A ring and an intramolecular dehydrative cyclization/olefin isomerization reaction to install the gamma-butenolide D ring.
4 citations