Showing papers on "Withania somnifera published in 1966"
TL;DR: The pyrazole alkaloid (I) has been isolated from the roots of Withania somnifera Dun (Solanaceae), which are used medicinally in India as mentioned in this paper.
75 citations
TL;DR: Several Steroidal 5,6expoxy-derivatives bearing an oxygen substituent at C4 have been synthesized and the stereochemistry of rings A and B studied.
18 citations
TL;DR: Withaferin A, the steroidal lactone isolated from the leaves of Withania somnifera Dun, has been degraded to bisnor-(5α)-cholanic acid as mentioned in this paper.
Abstract: Withaferin A, the steroidal lactone isolated from the leaves of Withania somnifera Dun. (Solanaceae), has been degraded to bisnor-(5α)-cholanic acid. The β-orientation of the 5,6-epoxide has been demonstrated by optical rotatory dispersion and n.m.r. data. Consequently, withaferin A is a 5β-steroid with the usual stereochemistry at all asymmetric centres, possessing a six-membered-ring lactone in the side-chain.
11 citations
TL;DR: In this paper, a new steroidal lactone isomeric with withaferin A has been isolated from the leaves of Withania somnifera Dun, which has been characterised as the title compound.
Abstract: A new steroidal lactone isomeric with withaferin A has been isolated from the leaves of Withania somnifera Dun. It has been characterised as the title compound.
10 citations
TL;DR: In this paper, the acid-catalysed rearrangement of the naturally occurring steroidal lactone withaferin A and of some of its derivatives has been investigated and the mass spectra of six significant compounds of this series are discussed.
Abstract: The acid-catalysed rearrangement of the naturally occurring steroidal lactone withaferin A and of some of its derivatives has been investigated. Deoxy-dihydrowithaferin A undergoes a pinacol type rearrangement in which contraction of ring A takes place leading to an A-nor-5-formyl derivative. A similar rearranged product has been obtained by the catalytic hydrogenation of deoxy-dihydrowithaferin A. Under acidic conditions, withaferin A yields, by loss of one ring-A carbon atom, a 2,5-dien-1-one. The mass spectra of six significant compounds of this series are discussed.
5 citations