Showing papers on "Withania somnifera published in 1989"
TL;DR: Two new glycowithanolides isolated from Withania somnifera Dun.
Abstract: Two new glycowithanolides, sitoindoside IX (1) and sitoindoside X (2), isolated from Withania somnifera Dun., were evaluated for their immunomodulatory and CNS effects (anti-stress, memory and learning) in laboratory animals, because the plant extract is used by practitioners of the Indian systems of medicine for similar purposes. The two compounds, in doses of 100–400 μg/mouse, produced statistically significant mobilization and activation of peritoneal macrophages, phagocytosis and increased activity of the lysosomal enzymes secreted by the activated macrophages. Both these compounds (50–200 mg/kg p.o.) also produced significant anti-stress activity in albino mice and rats and augmented learning acquisition and memory retention in both young and old rats. These findings are consistent with the use of W. somnifera, in Ayurveda, to attenuate cerebral function deficits in the geriatric population and to provide non-specific host defence.
152 citations
TL;DR: Five plants (Myrtus communis, Apium graveolens, Matricaria chamomilla, Withania somnifera and Achillea santolina) grown in Iraq were assessed for their anti-inflammatory activity on intact rats by measuring the suppression of carrageenan-induced paw edema produced by 1% of the intraperitoneal LD50 doses for the respective 80% ethanol extracts.
133 citations
TL;DR: Use of conductivity change in the medium for the on-line monitoring of cell mass growth was investigated and it was found that the effect of pH and sugar concentration changes on medium conductivity can be neglected.
64 citations
01 Jan 1989
TL;DR: It was found that the extracts of Myrtus communis, Peganum harmala and Withania somnifera exhibited significant activities in either the hot-plate test or in benzoquinone and/or acetic acid-induced writhing in mice.
Abstract: It was found that the extracts of Myrtus communis, Peganum harmala and Withania somnifera exhibited significant activities in either the hot-plate test or in benzoquinone and/or acetic acid-induced writhing in mice. The extracts of Artemisia herba-alba. Anchusa italica. Vicoo pentanema and Quercus infectoria failed to produce significant effects in either test at the doses used.
26 citations
Journal Article•
TL;DR: Withania somnifera Dun is a plant which drew the interest of many researchers in several countries, either for its active principles or for the extremely important pharmacodynamic or pharmacotherapeutic properties it has and first of all for the content in withanolides, substances with a sterol structure.
Abstract: Withania somnifera Dun is a plant which drew the interest of many researchers in several countries, either for its active principles or for the extremely important pharmacodynamic or pharmacotherapeutic properties it has and first of all for the content in withanolides, substances with a sterol structure.
10 citations
8 citations