Showing papers on "Withania somnifera published in 1992"
Journal Article•
TL;DR: Withania somnifera is a medicinal plant used in the treatment of a variety of ailments in the Ayurvedic system as discussed by the authors, and the root extract of the plant was injected at daily doses of 200 to 1000 mg/kg body wt for 15 days starting from 24 hr after intradermal inoculation of 5 x 10(5) cells of S-180 in BALB/c mice.
Abstract: Withania somnifera is a medicinal plant used in the treatment of a variety of ailments in the Ayurvedic system. Alcoholic extract of the root of the plant was injected(ip) at daily doses of 200 to 1000 mg/kg body wt for 15 days starting from 24 hr after intradermal inoculation of 5 x 10(5) cells of S-180 in BALB/c mice. Solid tumor growth was monitored for 100 days. Doses of 400 mg/kg and above produced complete regression of tumor after an initial growth, the percentage of complete response (CR) increasing with increasing drug dose. A 55% CR was obtained at 1000 mg/kg drug administration, but this dose also produced some mortality among the animals. A significant increase in the volume doubling time and growth delay was seen when the drug dose was increased from 500 to 750 mg/kg body wt, but further increase in drug dose to 1000 mg/kg did not produce any significant increase in these responses. Cumulative doses of 7.5 to 10 g at daily doses of 500 or 750 mg/kg seems to produce a good response in this tumor.
119 citations
TL;DR: The granuloma-tissue formation inhibiting activity of various fractions of an extract of the aerial parts of Withania somnifera were established using subcutaneous cotton-pellet implantation in rats and was comparable to that of a 5 mg/kg dose of hydrocortisone sodium succinate.
78 citations
TL;DR: The structure of a new chlorinated withanolide isolated from Withania somnifera chemotype III has been elucidated as 5α-chloro,6β,14α,17β,2Oα F -tetrahydroxy-loxo-22R-witha-2,24-dienolide by 1 H and 13 CNMR and chemical ionization mass spectroscopy methods as mentioned in this paper.
27 citations
TL;DR: Two new withanolides, sominone (1α,3β,27-trihydroxy-22(R)-witha-5,24-dienolide) (1) and sominolide (4β, 27-dihydroxy-14α,15α-epoxy-1-oxo-22-(R) witha-2,24dienoline) (2) were isolated from the herbs of Withania somnifera Dun (Solanaceae).
Abstract: Two new withanolides, sominone (1α,3β,27-trihydroxy-22(R)-witha-5,24-dienolide) (1) and sominolide (4β,27-dihydroxy-14α,15α-epoxy-1-oxo-22-(R)-witha-2,24-dienolide) (2) were isolated from the herbs of Withania somnifera Dun. (Solanaceae). The elucidation of their structures is based on extensive spectroscopic studies
20 citations
01 May 1992
1 citations