Showing papers on "Withania somnifera published in 1993"
Journal Article•
TL;DR: It is concluded that Ashwagandha, in addition to having a tumor inhibitory effect, also acts as a radiosensitizer and heat enhances these effects, as the inherent protection by the thiol will be highly reduced.
Abstract: Antitumor and radiosensitizing effects of alcoholic root extract of W. somnifera and their modification by heat were studied in vivo on Sarcoma-180 grown on the dorsum of adult BALB/c mouse. Ashwagandha (AT) was injected (ip) at a dose of 500 mg/kg body wt for 10 consecutive days into mouse bearing tumor of 50 +/- 5 mm3, with or without a local treatment of 10 Gy gamma radiation (RT) or hyperthermia at 43 degrees C for 30 min (HT) or both on 5th day of AT. The response was assessed on the basis of tumor regression, growth delay, animal survival and changes in the tumor GSH content. Ashwagandha, RT and HT individually produced 18, 38 and 45% complete response (CR) respectively, but RT gave the best long term survival. Ashwagandha increased the effect of radiation on tumor regression as well as growth delay, but AT + HT gave a better tumor cure. However, both these combinations gave almost identical long term survival, which was not much higher than that produced by RT alone. The combination of Ashwagandha for 10 days with one local exposure to RT followed by HT significantly increased the tumor cure, growth delay of partially responding tumors and animal survival. This combination also significantly and synergistically depleted the tumor GSH level, with no recovery even at 3 hr after treatment. It is concluded that Ashwagandha, in addition to having a tumor inhibitory effect, also acts as a radiosensitizer and heat enhances these effects. The severe depletion in the tumor GSH content by the combination treatment must have enhanced the tumor response, as the inherent protection by the thiol will be highly reduced.
90 citations
TL;DR: Two new withanolides named coagulin and withasomidienone have been isolated from Withania coagulance and Withania somnifera, respectively on the basis of spectroscopic studies.
Abstract: Two new withanolides named coagulin [17 beta,27-dihydroxy-14,20-epoxide-1-oxo-(22R)-witha-3,5,24-tr ienolide] and withasomidienone [27-hydroxy-3-oxo-(22R)-witha-1,4,24-trienolide] have been isolated from Withania coagulance and Withania somnifera, respectively. The structures have been determined on the basis of spectroscopic studies.
64 citations
21 Aug 1993
TL;DR: Subacute Toxicity Studies With Repeated Injections of Ashwagandha Extract At A Dose Of 100 Mg/Kg Body Wt.
Abstract: Alcohol Extracts From The Roots Of W. Somnifera (‘Ashwaganda’ In Sanskrit) Were Screened For Their Acute (24 H) Toxicity In Conventional Swiss Albino Mice and Subacute Toxicity (30 Days) In Wistar Rats. A Single Intraperitoneal Injection Of 1100 Mg/Kg Of The Extract In Mice Did Not Produce Any Deaths Within 24 H, But Small Increases Led To Mortality. The Ld50 Value Was Calculated As 1260 Mg/Kg Body Wt. Subacute Toxicity Studies With Repeated Injections Of Ashwagandha Extract At A Dose Of 100 Mg/Kg Body Wt. (= 1/12 Ld50) For 30 Days In Wistar Rats Of Either Sex Did Not Result In Any Mortality Or Changes In Peripheral Blood Constituents. However, Significant Reductions In The Weights Of Spleen, Thymus and Adrenals Were Observed In Male Rats At The End Of The Experiment. The Acid Phosphatase Content Of Peripheral Blood In Both Sexes Showed A Significant Increase From Control, While Other Biochemical Parameters Determined In The Study Were In The Normal Range.
45 citations
TL;DR: In conclusion, Withania somnifera (1000 mg/kg, oral) produced significant anti-inflammatory activity oncarrageenin-inducedpaw oedema, an acute inflammatory process in rats and was at its maximum at 2nd hour of administration and lasted for four hours during the course of observations.
Abstract: Sahni, Y.P. and Srivastava, D.N. 1993. Anti-inflammatory activity of Withania somnifera: Possible mode of action. J. Appl. Anim. Res. 3: 129–136. Withania somnifera (1000 mg/kg, oral) produced significant anti-inflammatory activity oncarrageenin-inducedpaw oedema, an acute inflammatory process in rats. The anti-inflammatory activity of W. somnifera was at its maximum at 2nd hour of administration and lasted for four hours during the course of observations. The sequential role of inflammatory mediators in anti-inflammatory activity of W. Somnifera is proposed through inhibition of histamine, 5-hydroxytryptamine and prostaglandins as the antagonists of these inflammatory mediators, viz promethazine, cyproheptadine and diclofenac, respectively, significantly potentiated the anti-inflammatory activity of W. somnifera. The time course of release of inflammatory mediators in the anti-inflammatory activity of W. somnifera is further proposed through inhibition of histamine and 5-HT (0–2 hours) in early ...
12 citations
Journal Article•
6 citations