Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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Journal Article•
27 citations
01 Jan 2011
TL;DR: The present study reveals standardization profile for drug like Withania somnifera D unal, which would be of immense value in botanical identification and authentication of plant drug and may help us in preventing its adulteration.
Abstract: Pharmacognostical standardization of dried, matured roots of Withania somnifera Dunal (Solonaceae) has been carried out in the present study. The study includes macroscopical and microscopical evaluation along with estimation of its physicochemical parameters such as ash and extractive values and preliminary phytochemical screening. It also includes quantification of some of the active constituents like alkaloids. The present study reveals standardization profile for drug like Withania somnifera D unal., which would be of immense value in botanical identification and authentication of plant drug and may help us in preventing its adulteration.
27 citations
TL;DR: There were distinct modulation in the immune response exhibited by the three chemotypes of Withania somnifera and NMITLI 101R appeared to possess a better immunostimulatory activity than the other chemotypes at lower doses.
27 citations
TL;DR: Results show that the a new species of withanolide, 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide (compound-1) could prove to be an effective agent to counteract C-H-R stress.
Abstract: Objective: Isolation of biologically active fractions and compounds from the roots of Withania somnifera, a plant used extensively as a constituent of rasayana, in Ayurveda and to test their adaptogenic activity on stress indices using the cold-hypoxia-restraint (C-H-R) model. Design: Bioactivity-guided fractionation of an aqueous extract of the roots of Withania somnifera led to the isolation of a new species of withanolide 1-oxo-5β, 6β-epoxy-witha-2-ene-27-ethoxy-olide. Structure elucidation, was carried out using proton nuclear magnetic resonance, infrared (IR), ultraviolet (UV), and mass spectroscopic analysis. Stress-related indices were evaluated, namely serum creatine phosphokinase (CPK) activity, serum lactate dehydrogenase (LDH) activity, serum corticosterone levels, and serum lipid peroxidation (LPO) levels. Results: There was a significant decrease in a serum CPK, LDH, and LPO levels in animals pretreated with (1) fraction-I (20 mg/kg body weight), (2) 1-oxo-5β, 6β-epoxy-witha-2-ene-27-ethoxy-o...
27 citations
TL;DR: Hochst et al. as discussed by the authors evaluated in vitro antibacterial, antiproliferative and antioxidant activities of methanolic leaf extracts and SGAFs of Solanum incanum L., S. schimperianum Hochst, S. nigrum L. and Withania somnifera (L) Dunal.
27 citations