Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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01 Jan 2000
20 citations
TL;DR: Two new withanolides, sominone (1α,3β,27-trihydroxy-22(R)-witha-5,24-dienolide) (1) and sominolide (4β, 27-dihydroxy-14α,15α-epoxy-1-oxo-22-(R) witha-2,24dienoline) (2) were isolated from the herbs of Withania somnifera Dun (Solanaceae).
Abstract: Two new withanolides, sominone (1α,3β,27-trihydroxy-22(R)-witha-5,24-dienolide) (1) and sominolide (4β,27-dihydroxy-14α,15α-epoxy-1-oxo-22-(R)-witha-2,24-dienolide) (2) were isolated from the herbs of Withania somnifera Dun. (Solanaceae). The elucidation of their structures is based on extensive spectroscopic studies
20 citations
TL;DR: It is suggested that Ws-Sgtl4 gene expression enhanced the production of total withanolide yield and withanolides-A in the hairy root culture of W. somnifera in the response to the elicitors.
Abstract: In Withania somnifera, sterol molecules of immense medicinal value are diversified by means of glycosylation. Identifying sterol glycosyltransferases provides an imperative insight of diverse sterol modifications, thereby helping to comprehend the underlying plant mechanisms. In the present study, one of the W. somnifera sterol glycosyltransferase-4 (Ws-Sgtl4) gene was transformed into the W. somnifera leaf explant through Agrobacterium rhizogene. Transformed W. Somnifera Ws-Sgtl4 leaf explants were subjected to hairy root induction and analyzed for biomass accumulation. The analysis of Ws-Sgtl4 gene expression was performed at different time exposures with the application of salicylic acid and methyl jasmonate. The elicitation of W. somnifera hairy root expressing the Ws-Sgtl4 gene was also evaluated for the enhancement if any, in the total withanolide yield as well as the withanolides-A contents. The results suggested that Ws-Sgtl4 gene expression enhanced the production of total withanolide yield and withanolides-A in the hairy root culture of W. somnifera in the response to the elicitors.
20 citations
Patent•
19 Apr 2006TL;DR: In this article, a cyclooxygenase-2 enzyme is used to inhibit withanolides from Withania somnifera, and the COX-2 inhibition is selective over COX 1.
Abstract: Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
20 citations
TL;DR: The chemical investigation on the n-hexane extract of Withania somnifera roots has yielded octacosane, oleic and stearic fatty acids, stigmasterone, Stigmasterol, sitostanone, oleanolic acid along with the ergosterol and 1,4-dioxane derivatives as new compounds.
20 citations