Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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TL;DR: Examination of medicinal plants and dietary supplements revealed that plant and supplements extracts exhibited medium or high cytotoxicity (only Dong quai—low), and antioxidant activity, total phenolics content and selected phytochemicals were analyzed by spectrophotometric and chromatographic methods.
Abstract: Mycotoxins and selected hazardous alkaloids in the medicinal plants (Panax ginseng, Angelica sinensis, and Withania somnifera) and dietary supplements were determined. Purine alkaloids were found in majority of samples; however, isoquinoline alkaloids were less abundant than indole. The predominant alkaloids appear to be caffeine (purine group), harman (indole group) and berberine (isoquinoline). Examined medicinal plants and dietary supplements were contaminated by mycotoxins (especially ochratoxin A 1.72–5.83 µg kg−1), and many species of mold (e.g. Cladosporium, Eurotium, Aspergillus, Rhizopus, Penicillium). MTT cytotoxicity tests revealed that plant and supplements extracts exhibited medium or high cytotoxicity (only Dong quai—low). Moreover, antioxidant activity, total phenolics content and selected phytochemicals were analyzed by spectrophotometric and chromatographic methods. Quercetin and rutin were predominant flavonols (1.94-9.51 and 2.20–7.28 mg 100 g−1, respectively). Analysis of phenolic acids revealed—gallic acid, as the most abundant, except Panax ginseng, where ferulic acid was prevailing. The results were analyzed by chemometric methods (cluster analysis, ANOVA).
16 citations
TL;DR: Significant morphological and physiological changes in GnV-3 cells after treatment with Ashwagandha extract are demonstrated and may suggest the potential beneficial effects of Ashwakandha on reproductive functions in vivo.
16 citations
TL;DR: A critical overview of the information on the metabolomics of W. somnifera is presented and the significance of the technique for use in quality control of medicinal products is highlighted and the use of metabolomics to distinguish varieties is pointed out.
16 citations
TL;DR: Exogenously applied melatonin mimics IAA activity in root growth and regulates well in 16-h light/8-h dark, thereby giving protection to plant system against light stress.
Abstract: Light plays a pertinent role in plant photo-morphogenesis and it is believed to have an impact on the melatonin-induced physiological functions. In the current study, different light regimes were employed with varying levels of melatonin, either singly or in combination with auxins for the growth and development of adventitious roots in Withania somnifera L. It was observed that 600 µM melatonin favored maximum adventitious root induction frequency (58 %) in cultures incubated under continuous dark conditions. However, adequate root growth (number and length of roots) was observed under 16 h light/8 h dark at 600 µM melatonin. Nevertheless, the interactive effect of light and melatonin was found stimulating for profound production of commercially important secondary metabolites. Correlation among growth parameters and biochemical markers was also observed in the current report. Data on total phenolic content and total flavonoid content were found at higher coincidence with each other and with DPPH antioxidant activity. In conclusion, exogenously applied melatonin mimics IAA activity in root growth and regulates well in 16-h light/8-h dark, thereby giving protection to plant system against light stress.
16 citations
TL;DR: Two new steroidal lactones of the withanolide type, isolated from Withania somnifera Dun (Solanaceae), are characterized by the unusual presence of a C-23 hydroxy-group.
Abstract: Two new steroidal lactones of the withanolide type, isolated from Withania somnifera Dun (Solanaceae), are characterized by the unusual presence of a C-23 hydroxy-group. Withanolide Q (1a) is (22S,23R)-17α,23,27-trihydroxy-1-oxowitha-2,5,24-trienolide and withanolide R (2a) is (22S,23R)-6α,7α-epoxy-5α,23-dihydroxy-1-oxowitha-2,24-dienolide.
16 citations