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Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


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Journal Article
TL;DR: The antioxidant, cytoprotective and related properties of Ashwagandha are found to be excellent, and it is able to retard the formation of 'cold cataract' in vitro, suggesting that Ashw Wagandha could well act as aCataracto-static agent.
Abstract: Cataract is the major cause of blindness the world over. Efforts to ease the cataract burden will be of great social and health economic benefit. Oxidative stress is known to be a major factor in age-related cataract of the eye lens. Regular systemic intake of antioxidant vitamins appears to retard the progression of cataract. These are beyond the reach of people in developing countries, who could, however, be encouraged to use antioxidant plant products that form part of their diet and traditional health practices. Ashwagandha (extract of the plant Withania somnifera) is one such product used in traditional medicine. We have studied the antioxidant, cytoprotective and related properties of Ashwagandha here, and find it to be excellent in these respects. It is also able to retard the formation of 'cold cataract' in vitro, suggesting that Ashwagandha could well act as a cataracto-static agent.

15 citations

Journal ArticleDOI
TL;DR: It is suggested that the chondroprotective effects and regenerative ability of these herbals are via the upregulation of survivin that exerts inhibitory effects on the p38 MAPK signaling pathway.
Abstract: Introduction: Inflammatory mediators are key players in the pathogenesis of osteoarthritis (OA) and bone destruction Conventional drugs suppress symptomatic activity and have no therapeutic influence on disease Cissus quadrangularis and Withania somnifera are widely used for the treatment of bone fractures and wounds; however, the cellular and molecular mechanisms regulated by these herbals are still unclear Methods: We established an in vitro OA culture model by exposing human chondrocytes to proinflammatory cytokine and interleukin (IL)-1 β for 36 hours prior to treatment with the herbals: C quadrangularis, W somnifera, and the combination of the two herbals Cell viability, toxicity, and gene expression of OA modifying agents were examined In addition, expression of survivin, which is crucial for cell growth, was analyzed In vivo work on osteotomized rats studied the bone and cartilage regenerative effects of C quadrangularis, W somnifera, and the combination therapy Results: Exposure of chondrocytes to IL-1β induced significant toxicity and cell death However, herbal treatment alleviated IL-1β induced cell toxicity and upregulated cell growth and proliferation C quadrangularis inhibited gene expression of cytokines and matrix metalloproteinases, known to aggravate cartilage and bone destruction, and augmented expression of survivin by inhibiting p38 MAPK Interestingly, osteotomized rats treated with C quadrangularis drastically enhanced alkaline phosphatase and cartilage tissue formation as compared to untreated, W somnifera only, or the combination of both herbals Conclusion: Our findings demonstrate for the first time the signaling mechanisms regulated by C quadrangularis and W somnifera in OA and osteogenesis We suggest that the chondroprotective effects and regenerative ability of these herbals are via the upregulation of survivin that exerts inhibitory effects on the p38 MAPK signaling pathway These findings thus validate

15 citations

Journal ArticleDOI
TL;DR: Microorganisms including bacteria, actinomycetes and fungi were recovered from the leaves of Withania somnifera, which were collected from two altitudinal ranges (0-300 m and 1700-2000 m) in the Asir region, Saudi Arabia, and pathogenicity was confirmed inside the leaf tissue.

15 citations

Journal ArticleDOI
TL;DR: It is concluded that supplementation of 20% WSR extract @ 20 ml/L of water caused a reduction in the severity, mortality, and recovery period of E. coli infection and enhanced the humoral and cellular immune responses suggesting its protective effect on limiting the pathology of E coli infection in broiler chickens.

15 citations

Journal ArticleDOI
TL;DR: The optimal temperature for germination is 25 °C and continuous light favored germination showing that photoperiod has a significant role, and the seedlings derived from seeds performed well when grown in a glasshouse.
Abstract: In order to evolve a quick method for smooth and optimum germination for Withania somnifera- a medicinally efficacious multipurpose plant, present investigation was carried to study the effect of physico-chemical treatments, storage, temperature, photoperiod and growth regulators (GA3, IAA, IBA, 2–4 D and BA) on germinability. The most effective treatment is GA3 at 150 μg/ml concentration at 25 °C. The optimal temperature for germination is 25 °C and continuous light favored germination showing that photoperiod has a significant role. The seedlings derived from seeds performed well when grown in a glasshouse. The data have implications for conservation and cultivation of the species studied.

15 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111