scispace - formally typeset
Search or ask a question
Topic

Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


Papers
More filters
Journal ArticleDOI
TL;DR: In this article, the variation of macro, micro and proximate components varied not only in the plants of different regions but also in the different parts of the same plant, with respect to the geographical, elemental composition and nutritional values.
Abstract: Withania somnifera (Linn.) Dunal is a subtropical shrub with important medicinal properties. The nutritive value and the elemental composition of different parts of plants, Withania somnifera which are grown in two distinct geographical regions (Sondekola and Karthikere) of Karnataka have been determined. The investigation revealed that the variation of macro, micro and proximate components varied not only in the plants of different regions but also in the different parts of the same plant. Among the macro elements, Karthikere samples recorded maximum values of nitrogen, phosphorous and magnesium and Sondekola samples recorded maximum values of sodium, potassium and calcium. Among the components of micronutrients, the highest values of iron were recorded both in Sondekola and Karthikere samples. The average values of manganese, copper and zinc were more in the Karthikere samples and comparatively less in the Sondekola samples. Whereas, all the samples of Sondekola recorded maximum values of nutrition. It is believed that the dry climatic condition of the region may contribute the high values of nutrition. Further, the observations are discussed with reference to the geography, elemental composition and nutritional values. The strong and negative observations on herbal drugs and their validity, the study emphasizes the role of elemental composition, proximate components, nutritive value, habitat and geographical features which influence growth and development of Withania somnifera and also herbal products of Withania somnifera in particular and medicinal plants in general.

14 citations

Journal ArticleDOI
TL;DR: The predicted pharmacological properties and structure activity relationship focuses that the compounds such as anaferine, anahygrine, cuscohygrine and isopelletierine can be CNS active and neuronal nicotinic acetylcholine receptor (nAChR) agonists.
Abstract: In Indian traditional practice of medicines, numerous plants have been used against various neurodegenerative disorders like Alzheimer's disease (AD). Withania somnifera (Ashwagandha in Sanskrit) i...

14 citations

01 Jan 2015
TL;DR: Endophytic fungus Fusarium sp.
Abstract: Nanotechnology has become a platform to alter and modify and develop the important properties of metal in the form of nanopaticles with its promising applications in various fields for the benefit of mankind. In the present study endophytic fungus Fusarium sp. was isolated from healthy leaves of Withania sominnifera (Ashwagandha) and was subjected for the extracellular biosynthesis of silver nanoparticles (AgNps). The synthesized AgNps were characterized using visual observation, UV-Vis spectroscopy and Transmission Electron Microscopy (TEM). Further AgNps synthesized were tested for their efficacy against the bacterial pathogens like E.coli, S.typhi and S.aureus. The formation of AgNps was confirmed by visual observation by change in colour from pale white to brown and the Surface Plasmon Resonance was determined by UV-Vis spectra at 422 nm. TEM revealed the formation of small sized spherical shaped nanoparticles ranging 12-20 nm. Antibacterial activity of AgNps against E.coli, S.typhi and S.aureus showed encouraging results, showing maximum zone of inhibition of 26mm, 26mm and 28 mm respectively at 60µl concentration of AgNps against E.coli, S.typhi and S.aureus.

14 citations

Journal ArticleDOI
TL;DR: It is proved that optimized formulation of Withania somnifera extract has possible anti acne property and will be a potential candidate as marketed product.
Abstract: Acne vulgaris is a disease of pilosebaceous unit which is characterized by non - inflam matory and inflammatory lesions. Common therapies that are used for the treatment of acne include topical, systemic, hormonal, herbal and comb ination therapy. So, for the treatment of acne h erbal anti acne cream is prepared containing Withania somnifera extract, which is known for its anti - inflamma tory action and antioxidant property. Herbal medications are considered safer than allopathic medic ines because allopathic medications are associated with different side - effects such as allergy, local irritation, scaling, photosensitivity reaction, itching, peeling , redness etc. The study includes macroscopical and m icroscopical evaluation of Withania s omnifera contai ning ash value, loss on drying , water extractive value , Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry and Ultraviolet Spectroscopy. The prepared formula t io n was optimized on the basis of in vitro rele ase study. T he optimized formulation was evaluated on the basis of greasiness , spreadability , after feel , skin irritancy , viscosity, pH and release kinetics. Anti bacterial s tudy by disc diffusion technique was performed. The result obtained was zone of inhibition of test 25.66 ± 1.12 and 5.89 ± 1.18 at 500 ppm , this proved that optimized formulation has possible anti acne property. So, further investigation such as in vivo studies will help this formulation to be a potential candidate as marketed product.

14 citations

Journal ArticleDOI
TL;DR: A review highlights the medicinal and therapeutic potential of withanolides against COVID-19 and identifies WFA as one of the most interesting naturally occurring bioactive compounds that possess potent anti-tumorigenic, antiinflammatory, pro-apoptotic, anti-angiogenic, and anti-invasive activities.
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the potentially fatal coronavirus disease 2019 (COVID-19), has currently affected over 87 million people with worldwide deaths nearing 1 9 million Amidst the developing vaccines and effective therapies, there is a need to develop alternative and supportive strategies for ameliorating the effects of SARS-CoV-2 infections in humans and treat COVID-19 patients Several medicinal plants and herbs contain useful phytochemicals, which are being explored to develop medicines and drugs to counter the COVID-19 pandemic Withania somnifera is a medicinal herb of growing importance that is extensively utilized in Ayurveda The medicinal attributes of W somnifera are owing to a broad range of bioactive secondary metabolites including steroidal lactones [withanone, withanolide D, withanolide A, and withaferin A (WFA)] Among these, WFA is one of the most interesting naturally occurring bioactive compounds that possess potent anti-tumorigenic, antiinflammatory, pro-apoptotic, anti-angiogenic, and anti-invasive activities It might bind to SARS-CoV-2 S protein and alter the S protein, thereby hindering its access into the host cells Withanone and Withanoside V can impede the functional activities of SARS-CoV-2 main protease (Mpro) Withanolides have been found to control cytokine secretions during infection and could alleviate the cytokine storm in the lungs The combined use of withanolides are several other drugs or therapeutic modalities, such as hydroxychloroquine and dexamethasone, has been demonstrated as an efficient strategy to improve the effectiveness of standard chemotherapy or design a robust therapeutic regime for COVID-19 treatment Nevertheless, exhaustive research efforts are required to explore the anti-inflammatory and immunomodulatory potentialities of withanolides for alleviating the severity of the disease during SARS-CoV-2 infections This review highlights the medicinal and therapeutic potential of withanolides against COVID-19 © 2021 Manish Dhawan et al This is an open access article distributed under the terms of the Creative Commons Attribution 4 0 International License (https://creativecommons org/licenses/by/4 0/)

14 citations


Network Information
Related Topics (5)
Antioxidant
37.9K papers, 1.7M citations
79% related
Essential oil
32.6K papers, 625.2K citations
78% related
Gallic acid
9.6K papers, 287K citations
78% related
Quercetin
7.7K papers, 333.3K citations
78% related
Antibacterial activity
18.4K papers, 322.4K citations
78% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111