Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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TL;DR: The present studies suggest that all the tested plants have moderate to potent antioxidant activity.
Abstract: The antioxidant properties of methanol extract of three medicinal plants viz. Withania somnifera, Asparagus racemosus and Centella asiatica that probably involve free radical mechanisms, were evaluated by the methods, namely the ABTS (2, 2’-azinobis-3-ethylbenzothiozoline-6-sulphonic acid) radical scavenging assay, Trolox equivalent antioxidant capacity assay (TEAC), Oxygen radical absorbance capacity (ORAC) assay, DPPH free radical scavenging activity assay, Super oxide scavenging activity assay and Nitric oxide radical scavenging activity assay. The methanol extract from Centella asiatica was most active in the ABTS assay with an IC50 value of 185.18 μg/mL followed by Withania somnifera with IC50 value of 214.78 μg/mL. The minimum activity showed by Asparagus racemosus with IC50 value of 384.55 μg/mL. The Trolox equivalent antioxidant capacity, DPPH (1, 1-diphenyl-2-picryl hydrazyl) and Superoxide radical scavenging activity of the methanolic extracts was in order of Withania somnifera > Centella asiatica > Asparagus racemosus. In the Oxygen radical absorbance capacity assay the ORAC value of Withania somnifera was found maximum 443.5 μ moles TE#/g and followed by Centella asiatica and Asparagus racemosus showed 211.5 μ moles TE#/g and 31.3 μ moles TE#/g respectively. The Nitric oxide radical activity was found in order of Asparagus racemosus >Withania somnifera > Centella asiatica. The present studies suggest that all the tested plants have moderate to potent antioxidant activity.
13 citations
TL;DR: Intra-nasal administration enables brain penetration of Withanolide A and allows the phytochemical to exert neuroprotective ability in the global cerebral ischemia model.
Abstract: 1. Withanolide A (WA), a major constituent phytochemical of the Ayurvedic herb Withania somnifera reportedly combats neurodegeneration in Alzheimer’s disease and Parkinson’s disease. But no study h...
13 citations
TL;DR: The morphotypes showed similar trend for dry root yield, whereas differences were observed for starch and crude fiber accumulation, and discussions on suitable harvest stage based on dryroot yield and starch–fiber ratio are made.
13 citations
TL;DR: An efficient and effective nested PCR-based system was developed and was sensitive enough to amplify phytoplasma DNA obtained from crude DNA diluted up to 2500 times from naturally infected plants and also from various stages of in vitro-propagated diseased plants.
Abstract: Withania somnifera is an important medicinal plant native to the Indian-sub continent. Owing to the presence of a number of precious alkaloids, flavonoids and withanolides, it is widely used in the Indian and African systems of medicines. It is severely affected by phytoplasma present in the sieve tubes of phloem. With a view to micropropagate phytoplasma-free W. somnifera plants, an efficient and effective nested PCR-based system was developed for detection of associated phytoplasmas. Universal primers, designed from the 16S rDNA sequences of phytoplasmas, were applied in direct/nested-PCR. Total DNA extracts from leaf tissues of 33 suspected symptomatic and 11 non-symptomatic plants were subjected to direct PCR. The direct PCR products were subsequently employed as templates in nested PCR. The nested PCR could reamplify direct PCR products yielding a DNA fragment of 1.4 kb. A phytoplasma was detected in all the diseased plants and not from the healthy looking plants. Further, it was sensitive enough to amplify phytoplasma DNA obtained from crude DNA diluted up to 2500 times from naturally infected plants and also from various stages of in vitro-propagated diseased plants. Identical restriction fragment polymorphism enzyme profiles were obtained following restriction enzyme digestion of nested PCR products, obtained from five different plants, by EcoRI, AluI and RsaI restriction endonucleases. The developed nested PCR based system should facilitate indexing of the phytoplasma in different stages of in vitro-generated plants and probably identification of, as yet unknown, hosts and vectors of phytoplasma associated with phytoplasma disease of W. somnifera.
13 citations
TL;DR: Both roots and shoots of W. somnifera contain herbicidal constituents against P. minor, one of the most problematic weeds of wheat in Pakistan, and are concluded to be comparatively less toxic than the methanol extracts.
13 citations