Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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TL;DR: The results indicated that The Trivedi Effect® - Biofield Energy Treatment might have an impact on the intrinsic physicochemical properties of the phytoconstituents present in the ashwagandha root extract.
Abstract: Withania somnifera (ashwagandha) root extract is very popular ancient herbal medicine. The objective of the study was to characterize and evaluate the impact of The Trivedi Effect®-Biofield Energy Healing Treatment (Energy of Consciousness) on phytoconstituents present in the ashwagandha root extract using LC-MS. Ashwagandha root extract was divided into two parts. One part was denoted as the control, while the other part was defined as The Trivedi Effect® - Biofield Energy Treated sample, which received Energy of Consciousness Healing Treatment remotely from eighteen renowned Biofield Energy Healers. The LC-MS analysis of the control and treated samples showed a very close retention time (Rt), indicated that the polarity of the phytoconstituents present in the root extract are same. The numbers of peaks observed in the total ion chromatograms were 28 and 29 in the control and treated samples, respectively. The change in the peak height% of the phytoconstituents in the treated sample was altered significantly within the range of -50.91% to 118.12% compared with the control sample. Similarly, the change in the peak area% of most of the phytoconstituents in the treated ashwagandha was significantly altered within the range of -54.95% to 66.95% compared with the control sample. An additional peak was appeared in the treated sample at Rt of 5.72 minutes, which was not found in the control sample. The LC-MS spectra indicated the presence of possible withanolides like -hydroxy-2,3-dihydro-withanolide F, withanolide A, withaferine A, withanone, withanolide D, ixocarpalactone A, withanolide S, thiowithanolide, etc. in both the samples. The peak are percentage (%) was altered in the identified withanolides, but withanolide sulfoxide was increased significantly by 12.44% in the treated sample compared with the control sample. These results indicated that The Trivedi Effect® - Biofield Energy Treatment might have an impact on the intrinsic physicochemical properties of the phytoconstituents present in the ashwagandha root extract. This could be the probable cause of alteration in the peak height, peak area, and appearance of a new peak in the treated sample. As a result, the concentrations of the phytoconstituents altered in the treated sample compared with the control sample. The treated ashwagandha root extract would be helpful for designing better pharmaceutical/nutraceutical formulations which might be providing a better therapeutic response against autoimmune diseases, nervous and sexual disorders, infectious diseases, antiaging, diabetes, cancer, ulcer, immunological disorders, stress, arthritis, etc.
10 citations
TL;DR: This preliminary study supports the therapeutic claim of the formulation as an anti-inflammatory drug in the Ayurvedic system of medicine and advocates its use in inflammatory conditions.
10 citations
TL;DR: A bioinformatics analysis was performed to look at functional and structural properties of enzymes involved in withanolides biosynthetic pathways of Withiana somnifera and predicted three-dimensional structures for these enzymes were predicted.
Abstract: Withania somnifera (Ashwagandha) is an affluent storehouse of large number of pharmacologically active secondary metabolites known as withanolides. These secondary metabolites are produced by withanolide biosynthetic pathway. Very less information is available on structural and functional aspects of enzymes involved in withanolides biosynthetic pathways of Withiana somnifera. We therefore performed a bioinformatics analysis to look at functional and structural properties of these important enzymes. The pathway enzymes taken for this study were 3-Hydroxy-3-methylglutaryl coenzyme A reductase, 1-Deoxy-d-xylulose-5-phosphate synthase, 1-Deoxy-d-xylulose-5-phosphate reductase, farnesyl pyrophosphate synthase, squalene synthase, squalene epoxidase, and cycloartenol synthase. The prediction of secondary structure was performed for basic structural information. Three-dimensional structures for these enzymes were predicted. The physico-chemical properties such as pI, AI, GRAVY and instability index were also studied. The current information will provide a platform to know the structural attributes responsible for the function of these protein until experimental structures become available.
10 citations
TL;DR: The results of the study indicated that Alternaria alternata caused severe leaf spot disease, while Myrothecium roridum and Fusarium oxysporum caused minor diseases, which were dominant seedborne pathogens that are transmitted to seedlings.
Abstract: Withania somnifera is a promising revitalizing medicinal herb. The plant is affected by foliar diseases in Lakkavalli forest region of Bhadra Wildlife Sanctuary. The symptomatology of foliar fungal disease incidence, severity and distribution in the study area was examined during 2006–2009. The seedborne nature and transmission of the causal pathogen and its management with seed dressing fungicides were studied. The results of the study indicated that Alternaria alternata caused severe leaf spot disease, while Myrothecium roridum and Fusarium oxysporum caused minor diseases. Based on the internal transcribed spacer (ITS1 and ITS2) regions of rDNA, the major pathogen was identified as A. alternata. The disease is homogeneously distributed in Lakkavalli forest region and high severity is recorded during November. Alternaria alternata and Fusarium oxysporum were the dominant seedborne pathogens that are transmitted to seedlings. Among the seed dressing fungicides used, Hyzeb was the most effective, followed ...
10 citations
Journal Article•
TL;DR: It is concluded that W. somnifera indeed has an anti-inflammatory potential and it, in combination with anAnti-oxidant like selenium, might successfully be used in the treatment of asthma.
Abstract: Summary The murine asthmatic Balb/c mouse model was used to investigate the effect of W. somnifera L., the antioxidant selenium, W. somnifera and selenium in combination and hydrocortisone as positive control on the number of white blood cells in blood smears and bronchial lavage smears as well as the platelet distribution of asthmatic Balb/c mice. The mice were sensitised, nebulized and treated over a period of 43 days and blood smears were made of each individual animal and bronchial lavage was performed by injecting 0.3ml of saline into the trachea of the mice, both on the day of termination. Light microscopy analysis of the bronchial lavage revealed a significant decrease in the number of eosinophils counted in the asthmatic and the different treatment groups. In the asthmatic group, numerous platelet clumps were found distributed between white blood cells. Platelets were also found in the other treatment groups but are not as prevalent as in the asthmatic group. Results from the blood smears showed the same trends, where cell counts in control and hydrocortisone blood smears were decreased compared to that of the asthma group. It is concluded that W. somnifera and W. somnifera combined with selenium significantly decreased the white blood cells in both bronchial lavage as well as blood smears, suggesting that W. somnifera indeed has an anti-inflammatory potential and it, in combination with an anti-oxidant like selenium, might successfully be used in the treatment of asthma.
10 citations