Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.

Membrane Stabilizing and Thrombolytic Activity of Withania somnifera Root

Abstract: In this present study, the root extracts of Withania somnifera were subjected to a comparative evaluation of the membrane stabilization and thrombolytic activity on human blood sample. The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte and the results were compared with standard streptokinase (SK) and standard anti-inflammatory drug, acetyl salicylic acid (ASA), respectively. The Methanol extract showed the highest thrombolytic activity (68.14%). On the other hand hypotonic solution induced haemolysis, at a concentration of 1.0 mg/ mL, the methanol extract inhibited 71.90% haemolysis of RBCs as compared to 73.56% produced by acetyl salicylic acid (0.10 mg/mL). And in case of heat induced condition different organic soluble materials of Withania somnifera demonstrated 54.03%, 53.13% and 38.54% inhibition of hemolysis of RBCs, respectively whereas ASA inhibited 48.10%.

PHARMACOGNOSTIC AND FREE-RADICAL SCAVENGING ACTIVITY INTHE DIFFERENT PARTS OF ASHWAGANDHA [Withania somnifera (L.Dunal)]

Abstract: Different parts of Ashwagandha [Withania somnifera (L Dunal)] were evaluated for their antioxidant against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and anti-lipid peroxidation activity Strong antioxidant scavenging activities were observed in mature root and young root bark portion Anti-oxidative efficiency to inhibit anti-lipid peroxidation of these plant extracts in goat liver was investigated Mature root bark of Ashwagandha showed higher class of antilipid peroxidation against thioburbituric acid but the stelar part of young root have low anti-lipid peroxidation activity The correlation was also drawn with antioxidants, its attributes and soil nutrients profile Pharmacognostic evaluation including examination of microscopical characters and determination of leaf constants (stomata frequency, stomatal index, palisade ratio, vein islets and vein termination number) were done for determining the authenticity of drug The observations from this study suggest the ethno-medicinal use of Ashwagandha which could be commercially exploited by the pharmaceutical industry for natural antioxidant

Inoculation with Selected Microbial Consortia not only Enhances Growth and Yield of Withania Somnifera but also Reduces Fertilizer Application by 25% under Field Conditions

Abstract: Inoculation with Selected Microbial Consortia Not Only Enhances Gr owth and Yield of Withania somnifera but also Reduces Fer tilizer Application by 25% Under Field Conditions N ANUROOPA1,*, D J BAGYARAJ2, ABHISHEK BAGELA3 and PRAKASH RAO4 1Department of Microbiology, Government Science College, Nrupathunga Road, Bangalore 560 001, India 2Centre for Natural Biological Resources and Community Development (CNBRCD), #41, RBI Colony, Anand Nagar, Bangalore 560 024, India 4Agarkar Research Institute, Pune, India 5Chief Scientist, CSIR Centre for Mathematical Modelling and Computer Simulation, NAL Belur Campus, Bengaluru, India