Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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Patent•
07 Dec 2007
TL;DR: In this article, the authors elucidate pharmacological action of Withanone contained in Withania somnifera leaf extract and provide a composition for new medicinal application and health application, based on the pharmacological actions.
Abstract: PROBLEM TO BE SOLVED: To elucidate pharmacological action of Withanone contained in Withania somnifera leaf extract and provide a composition for new medicinal application and health application, based on the pharmacological action. SOLUTION: The composition for lifetime extension of normal cell, induction and activity retention of proteasome activity of normal cell, protective action of normal cell from oxidative stress, protection of normal cell from DNA injury or chemical toxicity by ultraviolet light, treatment of activity of glucose-6-phosphohydrogenase (G6PD) or G6PD deficiency of normal cell, treatment action or prevention of tumor or cancer or sensitivity-enhancing action of cancer cell to anticancer agent comprises Withanone or its derivative as an active ingredient. COPYRIGHT: (C)2008,JPO&INPIT
6 citations
01 Jan 2011
TL;DR: The study revealed highest frequency of shoot formation and maximum number of shoots per explants in MS medium supplemented with 1mg/L BAP than the other growth hormone.
Abstract: An efficient protocol was devised for rapid in vitro propagation of Withania somnifera through shoot bud culture. The proliferating auxiliary shoot was isolated from nodal explants of field grown Withania somnifera. established on Murashige and Skoogs medium (MS) and Gamborg B5 medium supplemented with six concentrations of Benzyl amino purine (BAP), Naphthalene acetic acid (NAA), Kinetin(Kn) and 2,4Dichlorophenoxy acetic acid (2, 4-D). After 30 days of culture of Withania somnifera, the maximum numbers of shoots was produced on MS medium supplemented with 1.0mg/L BAP. Each of the explants had developed more than two shoots per nodes, while in six concentrations each of kinetin, NAA and 2, 4-D developed either two or less than two shoots/explants. The study revealed highest frequency of shoot formation and maximum number of shoots per explants in MS medium supplemented with 1mg/L BAP than the other growth hormone.
6 citations
Patent•
08 Dec 2000
TL;DR: In this paper, a method for screening plant metabolites and constituents to identify therapeutic agents and/or dietary supplements for treating diabetes has been proposed, which can be derived from plants such as Phyllanthus emblica, Azadiractha indica, Terminalia chebula, Mucunapuriens, Curcuma longa, Ficus glomerata, Phyllnthus niruri, Momordica charantia, Euphorbia royleana, Catharanthus roseus, Eugenia jambolana, Emblic
Abstract: The present invention provides therapeutic compositions derived from plants useful for treating diabetes. The present invention also provides methods for screening plant metabolites and constituents to identify therapeutic agents and/or dietary supplements for treating diabetes. The therapeutic compositions can be derived from plants such as Phyllanthus emblica, Azadiractha indica, Terminalia chebula, Mucunapuriens, Curcuma longa, Ficus glomerata, Phyllanthus niruri, Momordica charantia, Euphorbia royleana, Catharanthus roseus, Eugenia jambolana, Emblica officinalis, Gymnema sylvestre, Melia azadirechta, Morinda citrifolia, Pterocarpus marsupium, Tinospora cardifolia, Tribulus teristris, Trigonella foenum graecum , and Withania somnifera.
6 citations
TL;DR: The plant extract might act as potent free radical scavenger in fish tissues and have tissue protecting ability, thus increasing fish health, according to the evaluated immunological, haematological, biochemical and growth parameters.
Abstract: Efficacy of ethanol and methanol extracts of medicinal herb Withania somnifera roots was evaluated in Nile tilapia Oreochromis niloticus on immunostimulation and growth. Withania roots were extracted with water, ethanol, methanol, methylene chloride, hexane, successive methanol. Phenol, flavonoid content and antiradical activity of all the extracts were measured. Ethanol extract showed the highest phenol, flavonoid content and antiradical activity followed by methanol extract. Subsequently, Nile tilapia (n = 126) were fed diets containing different concentrations (0.0, 0.3, 0.5 and 0.7 g kg-1 feed) of ethanol and methanol extracts of W. somnifera roots for 30 days (3 replicates). Fish fed plant extract fortified diets showed significantly better (P<0.05) immunological, haematological, biochemical and growth parameters compared to the fish fed control diet. Fish fed diet containing ethanol extract at the concentration of 0.7 g kg-1 feed showed the highest immunological (phagocytotic activity, respiratory burst activity, serum lysozyme, total protein, total immunoglobulin), haematological (total red blood cells, haemoglobin, hematocrit, total white blood cells, lymphocyte), biochemical (reduced glutathione, glutathione reductase activity) and growth (final weight, weight gain, daily weight gain, specific growth rate) parameters. The plant extract might act as potent free radical scavenger in fish tissues and have tissue protecting ability, thus increasing fish health.
6 citations
TL;DR: The production and secretion of a recombinant pharmaceutically active protein from hairy roots cultures of Withania somnifera to improve the economic potential of this plant for the production pharmaceutical compounds is reported on.
6 citations