Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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01 Jan 2012
TL;DR: The in vitro antibacterial activity of Methanolic extracts of Withania somnifera (Solanaceae), was evaluated against sensitive bacteria and fungi, and the highest bio-activity was exhibited by the calyx extract against Pseudomonas aeruginosa.
Abstract: The in vitro antibacterial activity of Methanolic extracts of Withania somnifera (Solanaceae), was evaluated against seven Gram-negative bacteria, two Gram-positive bacteria and three fungi, using disk diffusion method followed by determination of minimum inhibitory concentrations by broth dilution method, against sensitive bacteria and fungi. Most of the extracts, at higher concentrations showed varying degrees of inhibitory activity against bacteria and fungi. The highest bio-activity was exhibited by the calyx extract against Pseudomonas aeruginosa. Staphylococcus aureus, Bacillus subtilis and Agerobacterium tumefaciens were the most sensitive pathogens after P. aeruginosa witch show maximum antimicrobial effects. Gentamycin and Ketoconazole, the standard antibiotics used were effective against the bacteria and fungi respectively.
5 citations
29 Jan 2018
TL;DR: Here, the classical motor symptom associated with accumulation of Lewy bodies and loss of dopaminergic neurons in the SNpc of the mid brain region and a complicated interplay between environmental factors and genetic factor that adversely affects the plentiful primary cellular processes are described.
Abstract: PD is a progressive neurological disorder of the central nervous system with growing layers of complexity. It is characterised by the classical motor symptom associated with accumulation of Lewy bodies (LB) and loss of dopaminergic neurons in the SNpc of the mid brain region. On the other hand, the symptomatology of PD is heterogeneous, with clinically significant non-motor characteristic. Likewise, the pathology of PD involves extensive regions of the central nervous system, a variety of neurotransmitters, and protein aggregates other than LB. The etiology of PD remains unknown, but probable risk of developing PD is not only due to environmental factors. Instead, PD seems to result from a complicated interplay between environmental factors and genetic factor that adversely affects the plentiful primary cellular processes. The major complexity Abstract
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01 Jan 1985TL;DR: Unlike non-steroidal anti-in-flammatory drugs, W. somnifera treatment resulted in a specific decrease in the synthesis of alpha-2-macroglobulin and enhancement in thehesis of total serum proteins suggesting the basis for its wide spectrum of pharmacological activities in diseases involving alterations of serum proteins.
Abstract: Withania somnifera Dun. herbal drug widely used in Indian medicinal systems, was examined for its effect on alpha-2-macroglobulin. Administration of W. somnifera to inflamed rats caused a significant reduction in the level of serum alpha-2-macroglobulin. Unlike non-steroidal anti-in-flammatory drugs, W. somnifera treatment resulted in a specific decrease in the synthesis of alpha-2-macroglobulin and enhancement in the synthesis of total serum proteins suggesting the basis for its wide spectrum of pharmacological activities in diseases involving alterations of serum proteins.
5 citations