Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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18 Dec 2013
TL;DR: Findings of present investigation showed that therapeutic potency of Ashwagandha ameliorate the toxicity produced during cancer chemotherapy by mitigating the bone marrow depression.
Abstract: C is used alone for the treatment of several types of cancers but often in combination with other drugs to treat breast cancer, leukemia and ovarian cancer or tumor but cyclophosphamide reduces the production of blood cells from the bone marrow. In the present investigation to combat the toxicity of cyclophosphamide, aqueous extract of immunomodulator plant like Ashwagandha was studied against toxicity of cyclophosphamide. After administration of cyclophosphamide @ 250 mg/kg b.w. orally by gastric intubation method to rats marked reduction in total count of WBC, RBC and platelets were observed on day 4. When Ashwagandha (300 mg/kg b.w.) was administered five days prior to cyclophosphamide administration and continued for ten days then significant increase in total count of WBC, RBC and platelets were observed after treatment. Thus, findings of present investigation showed that therapeutic potency of Ashwagandha ameliorate the toxicity produced during cancer chemotherapy by mitigating the bone marrow depression.
4 citations
TL;DR: In this article, the antioxidant potential and total antioxidant potential of Withania somnifera were determined by using reducing power determination method and phosphomolybdate method respectively.
Abstract: Withania somnifera is endemic to Ethiopia where its leaf and root is traditionally used for the treatment of malaria in south Ethiopia. The main purpose of this study was to investigate phytochemicals and antioxidant activity of the leaf extract of Withania somnifera. The anti-oxidant potential and total antioxidant potential was determined by using reducing power determination method and phosphomolybdate method respectively. As per the phytochemical tests, the methanol extract revealed that presence of tannins, phenolics, flavonoids, saponins and, alkaloids while all are absent in hexane extract. The antioxidant capacity of methanol, acetone and hexane leaf extracts of Withania somnifera were found to be 494.088±0.230, 104.190±0.020 and 3.413±0.023 mg of ascorbic acid per 10 mg of dry weight of antioxidant in the reducing power, respectively and it’s total antioxidant capacity of these extracts were 45.41±0.018, 8.70±0.004 and 0.38±0.002mg of ascorbic acid per 10 mg of dry weight of the crude extract. Thus, the results of the present investigation infer that this plant extracts possess potent antioxidant. Therefore it is strongly recommended to isolate the antioxidant components.
4 citations
TL;DR: In this article , withagenin A diglucoside (WAD) identified from Withania somnifera against TNF-α-stimulated human dermal fibroblasts is investigated.
Abstract: Human skin is constructed with many proteins such as collagen and elastin. Collagen and elastin play a key role in providing strength and elasticity to the human skin and body. However, damage to collagen causes various symptoms such as wrinkles and freckles, which suggests that they are important to maintain skin condition. Extrinsic or intrinsic skin aging produces an excess of skin destructive factors such as tumor necrosis factor (TNF)-α, which is a major mediator of the aging process. In aged skin, TNF-α provokes the generation of intracellular ROS (reactive oxygen species). It triggers the excessive secretion of MMP-1, which is a collagen-degrading enzyme that causes the collapse of skin collagen. Therefore, we aimed to search for a natural-product-derived candidate that inhibits the skin damage caused by TNF-α in human dermal fibroblasts. In this study, the protective effect of withagenin A diglucoside (WAD) identified from Withania somnifera against TNF-α-stimulated human dermal fibroblasts is investigated. W. somnifera (Solanaceae), well-known as ‘ashwagandha’, is an Ayurvedic medicinal plant useful for promoting health and longevity. Our experimental results reveal that WAD from W. somnifera suppresses the generation of intercellular ROS. Suppressing intracellular ROS generation inhibits MMP-1 secretion and the collapse of type 1 collagen. The effect of WAD is shown to depend on the inhibition of MAPK phosphorylation, Akt phosphorylation, c-Jun phosphorylation, COX-2 expression, and NF-κB phosphorylation. Further, WAD-depressed expression of the pro-inflammatory cytokines IL-6 and IL-8 triggers various inflammatory reactions in human skin. These findings suggest that WAD has protective effects against skin damage. Accordingly, our study provides experimental evidence that WAD can be a potential agent that can be applied in various industrial fields, such as cosmetics and pharmaceuticals related to skin aging.
4 citations
01 Jan 2018
TL;DR: In this chapter, an attempt is made to summarize the antineoplastic effects of Ashwagandha and its principal phytochemical, withaferin A, in various cultured neoplastic cell lines and the mechanisms involved.
Abstract: Withania somnifera (Ashwagandha), the member of Solanaceae family is recognized to be one of the most significant therapeutically known herbs in the traditional Indian system of medicine, the Ayurveda. In specific, its root is reported to be applied in the treatment of nervous exhaustion, insomnia, skin problems, and coughing. Scientific studies carried out in accordance to the modern system of medicine have shown that the plant extracts possess antimicrobial, anti-inflammatory, antioxidant, antiulcer, analgesic, anti-stress, wound healing, hepatoprotective, cardioprotective, antidiabetic, and immunomodulatory effects. In addition, studies have shown that withaferin A, the principal phytochemical of Ashwagandha, exhibits activity against inflammation, apoptosis, invasiveness, and angiogenic effects in various cancer progression conditions. In this chapter, an attempt is made to summarize the antineoplastic effects of Ashwagandha and its principal phytochemical, withaferin A, in various cultured neoplastic cell lines and the mechanisms involved.
4 citations
TL;DR: Ashwagandha [Withania somnifera (L.) Dunal] generally known as Indian ginseng is likewise named poison gooseberry or winter cherry and is native of North-western and Central India as well as the Mediterranean region of North Africa.
Abstract: Ashwagandha [Withania somnifera (L.) Dunal] generally known as Indian ginseng is likewise named poison gooseberry or winter cherry (Deshpande, 2005). Ashwagandha is an angiosperm plant that belongs to the Solanaceae family (Mir et al., 2013). It is a self-pollinated plant bearing chromosome no. 2n=48 (Nigam et al., 1995; Das et al., 2009), 2n=24 (Ram and Kamini, 1964), 2n=75 (Bir and Neelam, 1980). It is hardy and drought-tolerant perennial plant (Ali et al., 1997) that develops well in dry and subtropical regions having well-drained, sandy loam or light red soils (Kukreti et al., 2013) having pH of 7.5 to 8.0 with an average rainfall of 600-750 mm. Two species of Ashwagandha are found in India, viz. Withania sornnifera (L.) Dunal (Ashwagandha) and Withania coagulans (L.) Dunal (Panir). A few reports uncovered that alkaloid content found in Indian root ranges between 0.13 to 0.66 which is lower than 4.3 percent found at places other than India. Ashwagandha is native of North-western and Central India as well as the Mediterranean region of North Africa. It tends to be International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 11 (2020) Journal homepage: http://www.ijcmas.com
4 citations