Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.

A novel herbal formulation for the modulation of immune system of hiv infected patients and a process of preparation thereof.

Abstract: According to this invention, there is provided a novel herbal formulation for the modulation of immune system of hiv infected patients and a process of preparation thereof, comprising (i) preparing a hydromethanolic extract of at least one plant selected from Hippophae rhamnoides, Convolvulus pluricaulis, Withania somnifera, Ocimum sanctum, and Cynodon dactylon at 80-90°C, maintaining the pH of the solution between 6-7 (ii) separating the active compound chromatographically and (iii) subjecting the active compounds to the step of molecular characterization. Further, according to this invention there is provided a process for the preparation of novel plant based Ayurvedic formulation as claimed in claim-I comprising of preparing aqueous adding methanolic extract of Hippophae rhamnoides (Badriphal, Fruits), Convolvulus pluricaulis (Shankhapushpi, whole plant), Withania somnifera (Ashwagandha; Root), Cynodon dactylon (Durva, Whole plant) and Ocimum sanctum (Tulsi - Leaves), by using aqueous and methanol (50:50) at 80°-90°C temperature and maintaining pH of solution between 6-7, separating the active compound chromatographically of each plant material (extract) by using TLC, HPLC and HPTLC separation of the molecules of plant extract by using GCMS, LCMS and 2D NiVlR.

Anti inflammatory activity of a novel herbal combination

Abstract: A traditional herbal formulation containing Colchicum luteum, Butea frondosa, Withania somnifera. Pyrethrum indicum, Myrtus caryophyllus Zinziber officinalis and Allium cape was evaluated for anti-inflammatory activity in Rat paw edema models in albino rats. The activity was compared with that of the control and Indomethacin (25mg/kg body weight).The results indicate that the formulation, given orally, in the dosage of 100 mg/kg body weight and 200mg/kg body weight possess potent anti-inflammatory activity (P<0.01)

Evaluation of anti urolithiatic activity of withania somnifera in ethylene glycol induced urolithiasis in rats

Abstract: Objective : Evalution of Anti-Urolithiatic activity of Withania somnifera in ethylene glycol induced urolithiasis in rats. Abstract: Ethylene glycol (0.75%) and Ammonium chloride (1%) in water was used to induce urinary calculi for 28 days. Five groups were taken and six animals were taken in each group. From14 th day test drug Withania somnifera was given at 200mg/kg and 500mg/kg along with standard drug cystone 750mg/kg and all the group was compared with the positive control group. After completion of treatment after 24 hrs urine was collected and blood was collected by retro-orbital puncture and kidney histopathology was done. calcium, oxalate, inorganic phosphate, magnesium were analysed in urine and creatinine, BUN, uric acid in serum and calcium, oxalate and phosphate in kidney homogenate. Results and Discussion : Methanolic extract of Withania somniferashowed increase in urine volume and pH. All the treated groups showed decrease in calcium, oxalate, phosphate, creatinine, urea, and uric acid level in ethylene glycol induced lithiatic acivity. Conclusion : Methanolic extract of Withania somniferashowed significant anti-urolithiatic activity which is associated to its diuretic, anti-inflammatory and antioxidant property.

Withania somnifera Has Potential to Treat Cancer

Abstract: Withania somnifera is universally known as Ashwagandha in Ayurveda. Different parts of the Withania are used in medicinal and clinical applications. It possesses a lot of therapeutic action. Among them anticancer activity of Withania is the most interesting subject to research with. Recently in various studies Withania somnifera extract, different metabolites derived from Withania are found to show potent anticancer efficacy against various cancers including pancreatic, breast, lung, cervical, skin etc. The mostly studied Withaferin A (WA), a withanolide purified from Withania somnifera is an important bioactive molecule. WA showed promising inhibitory activity against various cancer cells in vitro and in vivo. WA induces apoptosis in cancer cells by stimulating pro-apoptotic proteins and inhibiting anti-apoptotic proteins. The mechanisms of action of WA in cancer cells are extensively studied all over the world. Withania somnifera could be use full medicinal herb as a potent chemotherapeutic agent in diverse clinical circumstances.

Amelioration of heat stress induced oxidative damage in broilers by supplementing Ashwagandha (Withania somnifera) extract during summer

Abstract: An experiment was conducted to elucidate heat stress alleviating effect of supplementation of Ashwagandha extract (WS) on growth performance, carcass traits, stress parameters and intestinal E. coli counts in commercial broilers reared during hot summer. Day old broiler chicks (n=160) were randomly allocated to 4 groups consisting of 8 replicates with 5 chicks each from 1 to 42 day of age. The four groups were 1. Positive control (PC) (Basal diet +Vit-E 70mg/kg + Se 0.15 mg/kg), 2. Negative control (NC)-basal diet without antioxidant, 3. WS50 (Basal diet + 50 mg WS extract/kg diet) and 4. WS100 (Basal diet + 100mg WS extract/kg diet). Body weight gain, feed efficiency, feed intake, intestinal E. coli counts were affected (P