Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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01 Apr 2017
TL;DR: The study revealed that the difference in in vitro shoot organogenesis of different chemotypes largely depends on the antioxidant protection system of the plant involving non-enzymatic compounds and activities of antioxidant enzymes.
Abstract: Withania somnifera (L.) Dunal, commonly called Indian Ginseng (Ashwagandha), is an important medicinal plant having a number of chemotypes which vary in their regenerative potentiality. In the present study, regenerative potentiality of four chemotypes of W. somnifera was compared using leaf explants. The study correlated that the chemotype (NIMTLI-130) with high total phenolic content (TPC), high H 2 O 2 concentration and low proline content was less regenerative, whereas, the chemotype (NIMTLI-101) with lesser TPC, lower H 2 O 2 concentration and high proline content was more regenerative. NIMTLI-130 showed higher SOD, GPX and APX activity compared to NIMTLI-101, but less CAT activity as well as low proline content and a weak detoxification effect resulting in lower regeneration. The study revealed that the difference in in vitro shoot organogenesis of different chemotypes largely depends on the antioxidant protection system of the plant involving non-enzymatic compounds and activities of antioxidant enzymes.
4 citations
TL;DR: A simple, rapid HPLC method for standardizing the mixture of extracts of three Medhya Rasayanas (neurotonic), Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri is developed and validated according to ICH guidelines.
Abstract: The use of herbs as medicine is an ancient form of healthcare known to mankind. Standardization of herbal medicines is however a challenging task and is the major bottleneck in their acceptance as the primary therapeutic option. The aim of this study was to develop and validate a simple, rapid HPLC method for standardizing the mixture of extracts of three Medhya Rasayanas (neurotonic), Convolvulus pluricaulis, Withania somnifera and Bacopa monnieri. Simultaneous estimation of the respective bioactive markers of these plants viz., scopoletin, withaferin A, bacoside A 3, bacopaside II, jujubogenin and bacosaponin C has been reported for the first time. The method was developed using Waters Hybrid X-Bridge shield with BEH technology 2.5 μm, 4.6 × 75 mm column and validated according to ICH guidelines. The 20 minutes run time makes the method eco-friendly. The method was linear over a range of 12.5-400 ng/10 μL for scopoletin and 62.5-2,000 ng/10 μL for withaferin A, bacoside A 3, bacopaside II, jujubogenin and bacosaponin C with detection limits of 8.0, 48.3, 30.4, 40.7, 15.6 and 18.9 ng/10 μL and quantification limits of 24.5, 146.5, 92.2, 123.4, 47.4 and 57.4 ng/10 μL, respectively. The correlation coefficient for each analyte was >0.999. The intra-day and inter-day precision was <2%. These results confirmed the precision, accuracy and robustness of the proposed method.
4 citations
01 Jan 2010
TL;DR: Results of the acute toxicity test, for oral as well as topical preparation of MFT09 and MFG09 respectively indicate that it is relatively safe and/or non-toxic to rats.
Abstract: Polyherbal formulations (MFT09 and MFG09) containing extracts of various plant constituents viz: Boswellia serrata, Commiphora wightii, Withania somnifera, Curcuma longa, Tinospora cordifolia, Zingiber officinale, Alpinia galangal, Cyperus rotundus and Vitex negundo, were evaluated for anti-inflammatory and analgesic activity. Antiinflammatory activity were investigated in albino wistar rats using Carageenan induced hind paw edema model, while the Radiant heat tail flick test was used as a model for evaluating analgesic activity. Treatment with MFT09 resulted in significant decrease in hind paw swelling as compared to MFG09. The effect of MFT09 produced significant analgesic activity against thermal induced pain stimuli in mice at various time intervals post treatment as indicating by increased latency to flick the tail which suggests that its activity might have resulted from its central action. Meanwhile, the results of the acute toxicity test, for oral as well as topical preparation of MFT09 and MFG09 respectively indicate that it is relatively safe and/or non-toxic to rats. The findings of these experimental animal studies indicate that MFT09 possesses potential anti-inflammatory and analgesic activity as compared to MFG09
4 citations
TL;DR: It is concluded that during photorefractoriness gonadal regression occurs due to testicular apoptosis which causes stress and Withania somnifera root extract (WSRE) helps to overcome stress and improve reproductive performance via increase in expression of ir-ERα during PR condition.
4 citations
TL;DR: Various aspects of this useful plant with reference to the phytochemicals, various biochemical activities, the extraction methods, and its antioxidant and antimicrobial activity have been tried to discuss.
Abstract: Universally the Ashwagandha (Indian Ginseng) could be referred as an extensively researched medicinal plant. It also holds an important place in the . It contains highly potent phytochemicals which are meticulously used as a tonic in for various ailments. Various aspects of this useful plant with reference to the phytochemicals, various biochemical activities, the extraction methods, and its antioxidant and antimicrobial activity have been tried to discuss in this paper. Information generated in this study shall be useful for undertaking research on genomic, transcriptomic, proteomic, metabolomics, and studieson . Charaka Samhita
4 citations