scispace - formally typeset
Search or ask a question
Topic

Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


Papers
More filters
01 Jan 2009
TL;DR: A poly herbal extract comprising of Withania somnifera Dunal, a medicinal plant used in many neuro protective Ayurvedic preparations along with five other medicinal plants were evaluated for its protective effect against seizures induced by Maximal Electro shock (MES) method in rats.
Abstract: With the introduction of allopathic drugs, the use of crude drugs from medicinal plants is on the decline and subsequently this traditional knowledge may be lost in the near future. In the present study, a poly herbal extract comprising of Withania somnifera Dunal, a medicinal plant used in many neuro protective Ayurvedic preparations along with five other medicinal plants were evaluated for its protective effect against seizures induced by Maximal Electro shock (MES) method in rats. A daily dose of 250 and 500 mg/kg of the extract was administered to the animals for 15 days, after which seizures were induced by Maximum electro shock method and the duration of various phases of epileptic attacks were recorded and compared with the control animals. A significant (P<0.01 and P<0.001) reduction in the time taken for righting reflex (recovery) was noted in the experimental animals. The levels of biogenic amines such as dopamine, serotonin and nor-adrenaline in the forebrain region were also estimated and a significant level of restoration was observed in the extract treated animals. Significant results were observed in the estimated parameters thereby justifying the use of these medicinal plants in the treatment of epilepsy.

4 citations

Journal ArticleDOI
01 Apr 2022-Genetica
TL;DR: In this article , the authors investigated the role of codon usage bias in the adaptability of pathogens to the host's environment for establishing parasitic relationship and found high similarity of CUB pattern between host and its nematode pathogen as compared to the fungal pathogen.
Abstract: Abstract Meloidogyne incognita (Root-knot nematode) and Alternaria alternata (fungus) were among the dominant parasites of the medicinal plant Withania somnifera . Despite the fatal nature of their infection, a comprehensive study to explore their evolution and adaptation is lacking. The present study elucidates evolutionary and codon usage bias analysis of W. somnifera (host plant), M. incognita (root-knot nematode) and A. alternata (fungal parasite). The results of the present study revealed a weak codon usage bias prevalent in all the three organisms. Based on the nucleotide analysis, genome of W. somnifera and M. incognita was found to be A-T biased while A. alternata had GC biased genome. We found high similarity of CUB pattern between host and its nematode pathogen as compared to the fungal pathogen. Inclusively, both the evolutionary forces influenced the CUB in host and its associated pathogens. However, neutrality plot indicated the pervasiveness of natural selection on CUB of the host and its pathogens. Correspondence analysis revealed the dominant effect of mutation on CUB of W. somnifera and M. incognita while natural selection was the main force affecting CUB of A. alternata . Taken together the present study would provide some prolific insight into the role of codon usage bias in the adaptability of pathogens to the host’s environment for establishing parasitic relationship.

4 citations

Journal ArticleDOI
TL;DR: The aim of the current work is to update the knowledge of SARS-CoV-2 infection and information about the implication of various compounds of medicinal plant Withania somnifera with minimum side effects on the patients’ organs.
Abstract: Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Bioactive compounds of Ashwagandha [Withania somnifera (L.) Dunal] may implicate as herbal medicine for the management and treatment of patients infected by SARS-CoV-2 infection. The aim of the current work is to update the knowledge of SARS-CoV-2 infection and information about the implication of various compounds of medicinal plant Withania somnifera with minimum side effects on the patients’ organs. The herbal medicine Withania somnifera has an excellent antiviral activity that could be implicated in the management and treatment of flu and flu-like diseases connected with SARS-CoV-2. The analysis was performed by systematically re-evaluating the published articles related to the infection of SARS-CoV-2 and the herbal medicine Withania somnifera. In the current review, we have provided the important information and data of various bioactive compounds of Withania somnifera such as Withanoside V, Withanone, Somniferine, and some other compounds, which can possibly help in the management and treatment of SARS-CoV-2 infection. Withania somnifera has proved its potential for maintaining immune homeostasis of the body, inflammation regulation, pro-inflammatory cytokines suppression, protection of multiple organs, anti-viral, anti-stress, and anti-hypertensive properties. Withanoside V has the potential to inhibit the main proteases (Mpro) of SARS-CoV-2. At present, synthetic adjuvant vaccines are used against COVID-19. Available information showed the antiviral activity in Withanoside V of Withania somnifera, which may explore as herbal medicine against to SARS-CoV-2 infection after standardization of parameters of drug development and formulation in near future.

4 citations

Journal ArticleDOI
TL;DR: Leaves of Acacia nilotica and Withania somnifera were tested for antibacterial activity which showed significant activity against Bacillus subtilis, Escherichia coli, staphylococcus and Pseudomonas fluorescence.
Abstract: Phytochemicals are essential compounds, utilized worldwide for curing of various human disorders. The present study comprised of 12 different medicinal plant species i.e. Withania coagulans, W. somnifera, Cannabis sativa, Medicago sativa, Achyranthes aspera, Convolvulus arvensis, Solanum nigrum, Mentha longifolia, Mentha spicata, Tagetes erecta, Fagonia cretica and Acacia nilotica. These species were used by the local inhabitants for treating various aliments. Methanolic extract of leaves of these plant species were investigated for cardiac glycosides, alkaloids, tannins, saponins, flavonoids, terpenoids, anthraquinones and reducing sugars. Among the reported medicinal plant species, Leaves of Acacia nilotica and Withania somnifera were tested for antibacterial activity which showed significant activity against Bacillus subtilis, Escherichia coli, staphylococcus and Pseudomonas fluorescence. Keywords: Medicinal plants; Phytochemical screening; Antimicrobial activity http://dx.doi.org/10.19045/bspab.2017.60042

4 citations

Journal ArticleDOI
01 Oct 2021-Heliyon
TL;DR: In this paper, the authors evaluated the 6-hydroxydopamine (6-OHDA)-induced toxicity in the human neuroblastoma SH-SY5Y cell line, as well as the associated oxidative response protein expression and redox regulation activity focused on Sglutathionylation.

4 citations


Network Information
Related Topics (5)
Antioxidant
37.9K papers, 1.7M citations
79% related
Essential oil
32.6K papers, 625.2K citations
78% related
Gallic acid
9.6K papers, 287K citations
78% related
Quercetin
7.7K papers, 333.3K citations
78% related
Antibacterial activity
18.4K papers, 322.4K citations
78% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111