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Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


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TL;DR: These results demonstrate MA efficacy against cognitive deficits as well as learning and memory impairment caused by ICV injection of STZ in rats and its potential in the treatment of some neurodegenerative disorders including SAD.
Abstract: (STZ) in rats is followed by long-term and progressive deficits in learning, memory, and cognitive performance in rats that is somewhat similar to sporadic Alzheimer’s disease (SAD). Epidemiological studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) could delay or slow the clinical expression of SAD. Objective(s): Therefore, the beneficial effect of mefenamic acid (MA) was investigated on ICV STZ-induced learning, memory, and cognitive impairment in male rats. Methods: For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected rats received MA (30 mg/kg/day, i.p.) starting from day 5 post-surgery for two weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, radial eight-arm maze (RAM) task was used. Results: It was found out that MA-treated STZ-injected rats show higher correct choices and lower errors in RAM than vehicle-treated STZ-injected rats. In addition, MA administration significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. Conclusions: These results demonstrate MA efficacy against cognitive deficits as well as learning and memory impairment caused by ICV injection of STZ in rats and its potential in the treatment of some neurodegenerative disorders including SAD.

2 citations

Journal Article
TL;DR: Ashwagandha (Withania somnifera) is a well-known herb possessing several health benefits as discussed by the authors, Steroidal alkaloids and lactones are the main active constituents of the plant.
Abstract: Ashwagandha (Withania somnifera) is a well-known herb possessing several health benefits. Steroidal alkaloids and lactones are the main active constituents of the plant. It consists of following properties viz. adaptogenic, antidepressant, liver-tonic, antioxidant, immune modulator, immuneadjuvant, anti-carcinogenic, anti-metastatic. Supplementation of Ashwagandha in diet of poultry birds improves feed intake, body weight gain, feed conversion ratio, hematological profile, immunological status, neuro-protective, rejuvenate muscles, lipid profile, gut microflora and intestinal morphometry. The effect of birds fed ration supplemented with Ashwagandha at different levels gradually improved feed intake, body weight, feed efficiency and nutrient metabolizability

2 citations

Journal Article
TL;DR: Withania somnifera is a pantropic native medicinal plant growing all over India belonging to family Solanacease, and is popularly known as “Ashwagandha” due to specific odour (smell of horses).
Abstract: Withania somnifera is a pantropic native medicinal plant growing all over India belonging to family Solanacease, and is popularly known as “Ashwagandha” due to specific odour (smell of horses). It holds a place in the ayurvedic traditional medicine similar to “Ginseng” in Chinese therapies. During present study SDS-PAGE divides the crude protein extract of seeds and root in 6–10 bands. Three active components were clearly identified by TLC in crude extract of seeds and root of Ashwagandha.

2 citations

01 Dec 2017
TL;DR: In this paper, the influence of different sucrose concentrations on the production of high secondary metabolite compounds was studied on Withania somnifera commonly known as Ashwagandha.
Abstract: Present work has been conducted on Withania somnifera commonly known as Ashwagandha to study the influence of different sucrose concentrations on the production of high secondary metabolite compounds. With the addition of different sucrose concentrations 30, 60, 90 g / L to MS medium in in vitro conditions, production of secondary metabolite compounds increased. Ten compounds with different production rates were produced. Production rate of compound 17hydroxy 27 deoxy withaferin, 27-hydroxy withanolide D and Withanone was maximum and significant under 30 g / L, 60 g / L, and 90 g / L sucrose treatment, respectively. However, MS medium containing 120 g / L sucrose led to burning of shoots and turned it in to brown.

2 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111