Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.

A prelim inary physico - chemical assay of ashwagandha granules a pilot study

Abstract: Withania somnifera , also known as Ashwagandha , Indian ginseng and winter cherry has been an important herb in the Ayurvedic and indigenous medical systems for over 3000 years. The roots of the plant are categorized as rasayanas , which are reputed to promote health and longevity by augmenting defence against disease and creating a sense of mental well being. Various researches support the use of Withania somnifera for anxiety, cognitive and neurological disorders. Ashwagandha contains steroidal compounds known as withanolides including withaferin A and withanolide A. These have been reporte d to be r e sponsible for significant biological activities and are recommended as active markers for standardization. In the present study an attempt was made to evaluate the physico - chemica l profile of Ashwagandha gran ules. Pharmacognostically authenticate d Withania Somnifera root powder was used for the preparation of Ashwagandha granules and it was analyzed through qualitative and quantitative analysis for physico - chemical parameters. Fingerprints of Thin Layer Chromatography (TLC) and High - Performance T hin Layer Chromatography study (HPTLC ) was also carried out.

Analgesic activity of a Withania somnifera extract in stressed mice

Abstract: Withania somnifera is an important Ayurvedic Rasayana herb, the roots of which are often used in traditionally known systems of medicine as tonic or for rejuvenation purposes Effects of a single and ten daily oral doses (10, 20 and 40 mg/kg) of an analytically well standardized Withania somnifera root extract against foot shock stress triggered transient hyperthermia and hotplate test for analgesics in male mice were quantified Body weights and basal rectal temperatures of animals were recorded on all observational days and on the 11th and 12th day of the experiment, all animals were subjected to tail suspension and pentobarbital hypnosis tests respectively Daily dose dependent efficacy of the tested extract in stress induced hyperthermia test and in hot plate test increased with increasing number of treatment days, and its dose dependent inhibitory effect on immobility time in tail suspension were observed after its 11 daily oral doses Daily handling and intermittent foot shock stress triggered body weight losses and elevations in basal core temperatures were almost completely prevented even by its lowest daily dose (10 mg/kg/day) tested Repeated daily low oral doses of the Withania somnifera extract is effective in suppressing diverse stress responses, and its centrally acting analgesics and anxiolytics or antidepressants like efficacies increase with increasing numbers of treatment days These observations reaffirm that Withania somnifera is an adaptogenic herb, and suggest that its effective therapeutic doses has to be adjusted according to the pre-existing allostatic load of patients

Seed protein characterization for morphotype identification in Withania somnifera (L.) dunal

Abstract: Characterization of five promising morphotypes, viz. AGB (Ashwagandha germplasm bank) -002, AGB-009, AGB-015, AGB-025 and AGB-030 of Withania somnifera have been made on the basis of seed protein profiles. SDS-PAGE of different morphotypes, revealed variation in number, width and intensity of bands. The molecular weight of protein bands by SDS-PAGE obtained varied between 29.0 to 97.5 kD (Kilo-dalton) in seeds of all morphotypes. There was morphotype specificity in electrophoretic pattern of seed protein. The observations revealed that seed protein polymorphism provides a useful information regarding variability among morphotypes under investigation. This offers a useful and rapidly performed adjunct to traditional morphological methods of identification in Withania somnifera.

Validated thin-layer chromatographic method for the identification and monitoring of the effect of the extraction method on the yield and phytochemical constituents of Egyptian Withania somnifera leaves.

Abstract: A sensitive, reliable, simple and rapid thin-layer chromatographic method has been developed for routine analysis of withanolide S content for the purpose of quality control assessment of chemotype III of Withania somnifera. The new method was used first to compare the accumulation of withanolide S in different parts of the plant, which was found to be the highest in the leaves extract (0.21% w/w). Second, to investigate different extraction parameters that improve the extraction efficiency of withanolides from the leaves using conventional and ultrasound-assisted extraction methods. The extraction efficiency was expressed via total withanolide content and withanolide S content.

Pharmacognostic and Nootropic Aspects of Withania Somnifera: A Potential Herbal Drug as Memory Enhancer

Abstract: Abstract: Withania somnifera is a well-known herbal drug commonly used in India and Indian subcontinent. It contains a spectrum of diverse phytoconstituents that are responsible for number of significant biological effects. Various parts of plants especially roots are rich in source of active phytoconstituents. In the current COVID-19 situation, various national and international agencies are suggesting the use of plant for increasing immunity as well as memory booster. The drug is mainly used in the management of brain related disorders such as anxiety, depression, stress, etc. The mainly used as memory enhancer as it increases the neurogenesis process in the brain. In present paper, we have covered the pharmacognosy, phytochemistry, and therapeutic applications of the plant related to the brain. Keywords: Withania somnifera; Memory enhancer; Roots; Stress.