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Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


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01 Jan 2009
TL;DR: The role of metal ions in conjugation with the withasteroids of Withania somnifera, on anti-stress activity in a cold restraint stress (CRS) model was investigated and WSE beneficently altered stress-induced changes in plasma corticosterone level in a significant way.
Abstract: Summary The role of metal ions in conjugation with the withasteroids of Withania somnifera, on anti-stress activity in a cold restraint stress (CRS) model was investigated. A standardized Withania somnifera extract (WSE, 100 mg/kg, p.o. x 7 days, prior to stress, and 5 days treatment during stress), administered to Swiss albino mice, of either sex, produced significant anti-stress activity when the animals were subjected to CRS. WSE beneficently altered stress-induced changes in plasma corticosterone level in a significant way. WSE also altered the stress induced changes in the levels of blood glucose, WBC count, weight of the organs (liver and spleen), MDA levels, plasma antioxidant profile (ABTS and FRAP), and lipid profile. WSE/excluded-I, (100 mg/kg, p.o.), comprising of strongly metal ion conjugated withasteroids and oligosaccharides, exhibited trends of further improvement, compared to those of WSE in these parameters. In contrast, metal ions-depleted bioactives of WSE, viz., WSE/excluded-II, showed only marginal anti-stress and antioxidant effects. These bioactivities were more pronounced at higher dose levels (200 mg/kg, p.o.) of the two extracts, WSE and WSE/excluded-I, indicating a dose-dependant relationship. Comprehensive chromatographic, spectroscopic and chemical analyses established the nature of metal ion-conjugation of withasteroids, comprising the withanolide aglycones, withanolide-indolealkylamines, withanolide glycosides, sitoindosides, and oligosaccharides.

2 citations

Journal ArticleDOI
TL;DR: The study concluded that inclusion of 0.5% W. somnifera with 0.05% synbiotic substance enriches the total protein content and reduces the total lipids content of broiler breast meat under heat stress conditions.
Abstract: Aim The present study was conducted to explore the effect of supplementation of Withania somnifera and synbiotics alone or in combination on the composition of broiler breast meat under heat stress conditions. Materials and Methods A 42-day feeding trial was conducted on 360 broiler chicks randomly allotted into eight treatment groups with three replicates each under completely randomized design. The T1 group was kept as control whereas T2-T4 were supplemented with 0.5%, 1%, and 1.5% W. somnifera root powder; T5 and T6 were supplemented with 0.025% and 0.050% synbiotic and T7 and T8 were fed on diet containing 0.25% W. somnifera+0.025% synbiotic and 0.50% W. somnifera+0.05% synbiotic, respectively. Three broilers from each replicate were sacrificed at the end of the trial to estimate crude protein (CP), ether extract and ash content of the breast muscle on dry matter basis. Results Significantly higher CP values and lower ether extract values were observed in 1.5% W. somnifera supplemented group (T4) or in group supplemented with 0.50% W. somnifera and 0.05% synbiotic (T8). The ash content of breast meat was observed non-significant in T1-T4 groups however the inclusion of synbiotics in T5-T8 groups significantly raised the ash contents. Conclusion The study concluded that inclusion of 0.5% W. somnifera with 0.05% synbiotic substance enriches the total protein content and reduces the total lipids content of broiler breast meat under heat stress conditions.

2 citations

Journal Article
TL;DR: Root and leaf extract showed their potential by decreasing the activity of ALT significantly in group III to VI birds in comparison to group II, however, the extract could not ameliorate the toxic effect of monocrotophos on LDH activity and creatinine level.
Abstract: The present study was conducted to investigate the protective efficacy of aqueous extracts of root and leaves of W.somnifera (Ashwagandha) against monocrtophos toxicity in broilers. Seventy two day old broiler chicks, were divided randomly and equally into six groups viz. Group I (Untreated Control), group II(MCP Control), W. somnifera root extract was given daily@ 100 and 300(mg/kg b.wt., orally) to group III and IV respectively in drinking water, W. somnifera leaf extract was given daily@ 100 and 300(mg/kg b.wt., orally)to group V and VI respectively in drinking water. On 21 day group II,III, IV, V andVI were administered single oral dose of MCP @ 1.34mg/Kg b.wt.(1/5th of LD50). There was no significant difference in haematological parameters in any of the experimental groups of birds after 1 day of single monocrotophos treatment except TEC which was significantly reduced in group II in comparison to group I birds. After 7 days there was a significant (P

2 citations

Journal ArticleDOI
01 Oct 2016
TL;DR: The results obtained indicate that the anticancer activity of isolated Withaferin-A was found potent growth inhibitor on MCF-7 cell line.
Abstract: The isolated Withaferin-A was screened for anticancer activity against MCF-7, U373-MG and OVKAR-3 Cell Lines. The preparative High Performance Thin Layer Chromatography (HPTLC) was used for isolation of Withaferin-A from the leaves of Withania somnifera grown in Karnataka and Nimuch region. The anticancer activity of isolated Withaferin-A was screened in vitro by Sulforhodamine B (SRB) assay considering LC50, TGI, GI50. The results obtained indicate that the anticancer activity of isolated Withaferin-A was found potent growth inhibitor on MCF-7 cell line. The Antiproliferative activity of isolated Withaferin-A gave GI50 values of <10, lower than standard Withaferin-A tested and at par with positive control. The anticancer activity of isolated Withaferin-A was comparable with standard Withaferin-A and Adriamycin control (<10ug/ml).

2 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111