Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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TL;DR: All extracts in the different polar solvents did not have or had very less antibacterial and antifungal activities.
Abstract: Aim: The aim of present study is to investigate the antimicrobial activity of (Flower, Ripen fruit and calyx) of Withania somnifera (RUBL20668) extracts, in order to use them as a possible source of new antimicrobial substances against important human pathogens. Materials and Methods: Crude extracts of different parts of both species of W. somnifera were evaluated against some important bacteria (two Gram +ve and four Gram-ve bacteria). Staphylococcus aureus (Gram +ve), Bacillus Subtilis (Gram +ve), Escherichia coli (Gram-ve), Raoultella planticola (Gram-ve), Pseudomonas aeruginosa (Gram-ve), Enterobactor aerogens (Gram-ve), one yeast Candida albicans and one fungus Aspergillus flavus . The dried and powdered seeds were successively extracted with hexane, toluene, iso propyl alcohol, acetone and ethanol, using the soxhlet assembly. The antimicrobial activity assay was done by both disc diffusion and serial dilution methods. Result: The results indicate that all the extracts in different polar solvents did not show any antibacterial activity against S. aureus , E. coli , R. planticola or E. aerogens or any antifungal activity against A. flavus . Conclusion: All extracts in the different polar solvents did not have or had very less antibacterial and antifungal activities.
2 citations
2 citations
TL;DR: Ps a herbal feed additive was beneficial in improving average weekly body weight gain, feed conversion ratio and blood biochemical profile in broilers during 0-6 weeks of age.
Abstract: An experiment was conducted on one hundred eighty day old commercial broiler chicks (Ven Cob Strain) to study the effect of Withania somnifera (Ashwagandha) root powder as feed additive on the performance and blood biochemical profile in broilers during 0-6 weeks of age. The chicks were randomly divided into three groups 60 each. All the chicks were housed in deep litter system. The experimental diets were: no feed additive (T0), 0.25 per cent Ashwagandha root powder (T1) and 0.5 per cent Ashwagandha root powder (T2). Body weight gain of T1 (567.00 g) and T2 (581.67 g) was significantly (Ps a herbal feed additive was beneficial in improving average weekly body weight gain, feed conversion ratio and blood biochemical profile.
2 citations
TL;DR: Withaferin A, a natural bioactive molecule isolated from the Indian medicinal plant Withania somnifera (L.) Dunal, has been reported to impart anticancer activities against various cancer cell lines and preclinical cancer models by modulating the expression and activity of different oncogenic proteins as mentioned in this paper .
Abstract: Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer treatment. Unfortunately, these treatment options suffer from major limitations, such as drug-resistance and adverse effects, which may eventually result in disease recurrence. Many phytochemicals have been investigated for their antitumor efficacy in preclinical models and clinical studies to discover newer therapeutic agents with fewer adverse effects. Withaferin A, a natural bioactive molecule isolated from the Indian medicinal plant Withania somnifera (L.) Dunal, has been reported to impart anticancer activities against various cancer cell lines and preclinical cancer models by modulating the expression and activity of different oncogenic proteins. In this article, we have comprehensively discussed the biosynthesis of withaferin A as well as its antineoplastic activities and mode-of-action in in vitro and in vivo settings. We have also reviewed the effect of withaferin A on the expression of miRNAs, its combinational effect with other cytotoxic agents, withaferin A-based formulations, safety and toxicity profiles, and its clinical potential.
2 citations
Journal Article•
TL;DR: A study to assess the genuineness of Ashwagandha available in herbal raw drug markets of Kerala found the samples got from each of 14 districts of Kerala to be genuine.
Abstract: Withania somnifera (Linn.) Dunal (Solanaceae) is a very important ayurvedic herb used from time immemorial. The Ayurvedic Pharmacopoeia of India (API) mentions root of Withania somnifera (Linn.) Dunal as the officinal part of Ashwagandha. In Kerala, it is used in a variety of formulations either as single or in combinations. But there is a huge difference between its demand and availability. So the study was undertaken to assess the genuineness of Ashwagandha available in herbal raw drug markets of Kerala. For this purpose, 28 commercial samples (one from urban and one from rural) of Ashwagandha was collected from each of 14 districts of Kerala and its characters were compared with the root collected from the genuine source plant of Ashwagandha [Withania somnifera (Linn.) Dunal] and also with the standards mentioned for Ashwagandha in API. There was great difficulty in procuring original Ashwagandha because it is not cultivated in Kerala. So it was collected from Bhopal in Madhyapradesh where the best variety of Ashwagandha is obtained, which is called ‘Nagori Ashwagandha’ Comparisons were done with the aid of macroscopic evaluation which is a part of Pharmacognostical evaluation. The result got from each of these matched with that of genuine sample and the standards given in API. So the samples got from each of the 14 districts of Kerala are thus found to be genuine.
2 citations