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Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


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Journal ArticleDOI
TL;DR: In this paper, the search for therapeutic small molecules and vaccines for Covid-19 treatment is an urgent but evolving topic, which has claimed over 3,782,490 lives (as of 12 June 2021).
Abstract: The search for therapeutic small molecules and vaccines for Covid-19 treatment is an urgent but evolving topic. The virus has claimed over 3,782,490 lives (as of 12 June 2021), with the figure expe...

1 citations

Journal ArticleDOI
TL;DR: The result indicates that the Withanolide–A exhibited significant antibacterial activity against the Pseudomonas and Staphylococcus aureus.
Abstract: The increasing prevalence of multidrug resistant strains of bacteria and the recent appearance of strains with reduced susceptibility to antibiotics raises the specter of untreatable bacterial infections and adds urgency to the search for new infection-fighting strategies. The WHO estimated that approximately 80% of world population relies mainly on traditional medicines, mostly plant drugs in their health care. About 30% of the currently used therapeutics is of natural origin. Withania somnifera Dunal is widely used in Ayurvedic medicine, the traditional medical system of India. The alkaloid (Withanolide –A) was obtained from 50% ethanol extract of Withania somnifera stem, subjected to column chromatography on silica gel eluted with a stepwise gradient of increasing order (Ethyl acetate: hexane). White crystals in ethyl acetate were obtained from ethyl acetate: hexane fraction. The aim of the present study was to investigate the in vitro antibacterial activity of the alkaloid, was screened against pathogenic bacteria of clinical origin including two species, Pseudomonas and Staphylococcus aureus. The growth inhibition was observed in four of the five tested pathogens at three different of Withanolide-A concentrations (100, 500, and 1000 ppm).The result indicates that the Withanolide–A exhibited significant antibacterial activity against the Pseudomonas and Staphylococcus aureus.

1 citations

Journal ArticleDOI
TL;DR: The results of this study qualify Sardinian W. somnifera berries as an interesting source of oils with nutritional properties, with higher total level of monounsaturated fatty acids than seed oil.

1 citations

01 Jan 2016
TL;DR: In this article, a polyherbal preparation (POL-6) was developed and standardized and evaluated its use in treating oxidative, inflammatory and immune disorders, and the results obtained from physical and chemical parameters evaluation shows that the contents of preparation present are within permissible limits.
Abstract: Objective: The objective of this study was to develop and standardize a polyherbal preparation (POL–6) and evaluate its use in treating oxidative, inflammatory and immune disorders. Methods: The individual hydroalcoholic extractions of Hypericum perforatum, Bacopa monnieri, Centella asiatica, Withania somnifera, Ocimum sanctum and Camellia sinesis dried plant materials were done, and POL–6 was prepared by mixing them in (1:2:2:2:2:1) proportions. POL–6 has been standardized on the basis of organoleptic properties, physical characteristics, and physicochemical properties. The antioxidant activities were evaluated using free radical scavenging methods for 1,1–diphenyl–2–picrylhydrazyl, (DPPH) and nitric oxide assays. Anti–inflammatory activity was done by albumin denaturation and HRBC membrane stabilization assays. Cell viability assay was used for immunomodulatory activity measurement by cultivating peripheral blood mononuclear cells. Results: The results obtained from physical and chemical parameters evaluation shows that the contents of preparation present are within permissible limits. In in–vitro antioxidant studies POL–6 showed significant antioxidant activity when tested in 1–1 Diphenyl–2–picrylhydrazyl and nitric oxide assays. In in–vitro anti‐inflammatory investigation, POL–6 exhibited significant inhibition against albumin denaturation and significant protection against membrane stabilization assay. POL–6 also exhibit significant immunomodulatory activity at low doses, when tested in cell viability assay. Conclusion: The results from this study rationalize the medicinal use of POL–6 in oxidative, inflammatory and immune disorders.

1 citations

Journal ArticleDOI
01 Nov 2016
TL;DR: In this paper, a study was carried out to evaluate the protective effect of fortified cake by different concentrations of ashwagandha root powder against sodium arsenite induced toxicity in rats.
Abstract: In ayurvedic medicine, herbal plants as ashwagandha (Withania somnifera) were used as a powerful plant to cure many of diseases. The present study was carried out to evaluate the protective effect of fortified cake by different concentrations of ashwagandha root powder against sodium arsenite induced toxicity in rats. Thirty male Sprague-Dawley rats weighing (120 ± 10g).Rats classified into to five groups (6 rats). The first group was kept as a negative control and fed on the basal diet only. Other four groups were administered sodium arsenite at a single dose of 5 mg/kg/day to induce toxicity injury. One of these groups left as positive control (group 2). The third group was treated with 100% wheat flour fortified cake. The fourth group was treated with 10 % ashwagandha powder fortified cake. The fifth group was treated with 20 % ashwagandha powder fortified cake. Laboratory analysis showed that fortification with ashwagandha inhibited the levels of liver injury biomarkers, also improved the kidney function enzymes. These results suggested that ashwagandha has a powerful antioxidant effect which can reduce organ injury through its ability by scavenge the free radical.

1 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111