Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.

A New Antifeedant Withanolide from Jaborosa lanigera.

Abstract: The withanolides are a group of natural C28steroidal lactones built on an intact or arranged ergostane framework that occurs mainly in plants of certain genera of Solanaceae. The first member of this group of compounds, withaferin A, was isolated from the well-known Indian medicinal plant, Withania somnifera [1] and its structure was fully elucidated by Lavie and coworkers in 1965 [2]. The withanolides exhibit a variety of biological activities as antifeedant, immunosuppressive and cancer chemoprevention activity [3]. Jaborosa Miers is a South American genus belonging to the Solanaceae family that comprises about 23 species, 11 of which are almost exclusively distributed in Argentina [4]. Previous studies on populations of J. laciniata, J. magellanica, J. leucothrica and

Pharmacognostical and Pharmacological Evaluation of the Polyherbal Extract on Rodents

Abstract: Hyperlipedemic is the greatest risk factor for coronary heart diseases. It is characterized by elevated serum total cholesterol, low density lipoprotein, very low density lipoprotein and decreased high density lipoprotein levels. Methanolic extract of Terminalia arjuna (bark), Phyllanthus emblica (fruits), Withania somnifera (leaves), Convolvulus pluricaulis (whole plant), Piper betle (leaves), Allium sativum (bulb), Piper longum (dry fruits), Zingiber officinale (rhizomes), Tribulus terrestris (whole plant) and Cardamom (dry fruits) these herbs were tested against high cholesterol diet induced hyperlipedemic in adult albino rats. The therapeutic dose is calculated as 200mg/kg as per the toxicity guidelines OECD 423. Fenofibrate 65mg/kg is used as a standard drug. The methanolic extracts shows a significant decrease in the levels of serum cholesterol, Triglycerides, LDL, VLDL and significant increase in the level of serum HDL against high cholesterol diet induced hyperlipedemic rats. The results shows that the polyherbal extract possess significant (p<0.001) antihyperlipedemic activity suggesting the potential role in coronary artery disease and in hyperlipidemia.

Odabrane biljne vrste tradicionalne indijske medicine s adaptogenim svojstvima

Abstract: Objectives The aim of this paper is a systematic review of the five widely used herbs from traditional Indian medicine. The herbs selected should have relevant clinical studies having in mind the actions and safety of their herbal preparations. The selected herbs are Asparagus racemosus (Sanskrit, shatavari), Ocimum tenuiflorum (Sanskrit, tulsi), Phyllanthus emblica (Sanskrit, amalaki), Tinospora cordifolia (Sanskrit, guduchi) and Withania somnifera (Sanskrit, ashwagandha). Materials/Patients and Methods For the search is used electronic database PubMed with the keywords that include Latin, English, and Sanskrit plant names and known synonym of the selected spices. Scientific papers have been studied based on their summary and are limited to clinical studies, published in English, of the selected plant species. Papers matching the selected criteria were to be included regardless of the date of their publication. Results This paper selected and researched a total of 76 clinical studies of the selected adaptogenic plants within traditional Indian medicine. The work includes 6 clinical studies for the species Asparagus racemosus, 15 studies for Ocimum tenuiflorum, 27 studies for Phyllanthus emblica, 10 studies for Tinospora cordifolia and 18 studies for species Withania somnifera. The selected plant species showed significant efficacy and tolerance in the published and researched clinical studies analysed in this paper. The herbal species A. racemosus is effective in treating digestion problems. Spices O. tenuiflorum demonstrated significant antimicrobial activity. The plant P. emblica has also been shown to have antimicrobial activity but has also proven effective in treating many modern diseases, particularly diabetes type II, and as an anti-inflammatory agent. The studies showed that spices T. cordifolia modulates lipid metabolism, reduce blood glucose levels, enhance immune processes in the body and acts as an immunomodulator. Perhaps the most popular plant species in the West, W. somnifera or ashwagandha, has shown positive effects on the neurological diseases, improving the cognitive function of the organism. Studies have also shown that it reduces oxidative stress, which may be one of the reasons for W. somnifera’s effectiveness in normalizing thyroid function and reducing infertility in women and men. Conclusion A review of 76 clinical studies included in this paper revealed that the selected plant species showed the efficiency and a positive effect on the organism. They support defence mechanisms, increase resistance to stress and improve physical, and mental health. This partly justifies their classification as adaptogens, however, additional welldesigned clinical studies with standardised herbal preparations are needed to thoroughly examine their efficacy and safety.

Effect of extract of Withania somnifera on fruit rot of tomato caused by Aspergillus niger in presence of Drosophila busckii

Abstract: Association of insect Drosophila busckii Coq. with the fruit rot fungus, Aspergillus niger Van Tiegh. enhances the rotting of tomatoes. Chemicals can not be used to manage the insect and the fungus together due to hazards to human. Moreover, there is great specificity in the chemicals to control and thus no Single chemical can be used to manage these two together. Withania somnifera Dunal is known to have alkaloids and related substances known for antimicrobial properties. With this view, it was desired to study the efficacy of the extract of this plant against both the insect and the fungus and the resultant fruit rot development

Effect of Different Auxins Alone and Mixture of Benzene Aminopurine (BAP) and Kinetin (Kn) Along with Auxin 2,4-D on In Vitro Growth and Multiplication of Callus in B5 Medium Derived from Embryonic Cotyledon Excised Explants of Ashwagandha (Cultivated)

Abstract: Ashwagandha (Withania somnifera) belongs to the member of family Solanaceae, having enormous aromatic properties and medicinal properties, has been included in an ancient (early) text of Ayurveda It is very useful as an, contraceptive, amoebocide, bactericide, abortifacient, anodyne, and diuretic But the risks of fungal infections are very high in these plants Due to its over use this plants is going towards extinction so in vitro microprogation is a best method to protect this plant as well as to produced value added compounds in a very short time without any external environmental hazards Higher percentage of in vitro morphogenic response was exhibited by explants mature embryo followed by explants mature cotyledon leaves Half B5 medium (gamborg medium) with NAA, IBA, 2,4- Di-chlorophenyl acetic acid (2,4-D), BAP, Kinetin (Kn) and Sucrose (5% w/v) was employed either separately or in mixture Cotyledonary leaves are generally produces callus in callus induction media and after several sub culturing its produces shoots and roots in shoot and root induction media Regenerated plantlets were obtained successfully in the field after hardening Mostly for in vitro organogenesis MS medium has been employed bus it has been also done in B5 medium with cotyledonary leave's explants of Withania somnifera