Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
Papers published on a yearly basis
Papers
More filters
30 Dec 2014
TL;DR: In this paper, the authors made an attempt to elevate the importance of this herbal source by understanding its antioxidant scavenging activity and found that methanol and chloroform extracts of W. somnifera, has higher antioxidant activity when compared with the standard Vitamin C was observed using the graph plotted as the percentage of inhibition of scavenging activities vs concentration and IC50 value was observed to be nearly 50 μg/mL for all the tests.
Abstract: Due to an increase in modernization, people suffer from various stresses related and sexual problems. In India, with various herbal reservoirs, Withania somnifera (Ashwagandha) plays an important role in treating the vital and vigour problem as well as in treating sexual problems. We made an attempt to elevate the importance of this herbal source by understanding its antioxidant scavenging activity. We have utilized the powder of this plant fruit and processed using different solvents in 1:10 dilution by dissolving with 3g of powder with 30ml of each solvent such as petroleum ether, chloroform ethanol, hexane, methanol and distilled water. It was found that methanol and chloroform extracts of W. somnifera, has higher antioxidant activity when compared with the standard Vitamin C was observed using the graph plotted as the percentage of inhibition of scavenging activity vs concentration and IC50 value was observed to be nearly 50 μg/mL for all the tests.
1 citations
Journal Article•
1 citations
TL;DR: It is concluded that therapeutic modulation of redox mechanisms may aid in the clinical management of subclinical diabetes mellitus, however, the mechanisms involved should be further explored.
Abstract: Background: The present study evaluated the antioxidant as well as the anti-diabetic potential of Terminalia chebula (Haritaki) and Withania somnifera (Ashwagandha) in subclinically diabetic dogs.Methods: A total of thirty subclinically diabetic dogs were divided into five groups of six animals each; Group I (Positive control), Group II (T. chebula extract), Group III (W. somnifera extract), Group IV (T. chebula and W. somnifera extracts at 1:1 ratio) and Group V (N- acetylcysteine). Six apparently healthy dogs were kept as negative control (Group VI) for the study. The animals were evaluated based on diabetic biomarkers (Random blood glucose, fasting blood glucose, glycated hemoglobin, serum fructosamine and serum insulin) and oxidative stress markers (lipid peroxidation, reduced glutathione, superoxide dismutase and catalase activities) on days 0, 15 and 30 of the study.Result: Significant oxidative stress was observed in the subclinically diabetic dogs and the supplementation of N- acetylcysteine, T. chebula and W. somnifera effectively curbed the oxidative impairments and further progression of diabetes. The improvement in oxidative, as well as diabetic biomarkers, was predominant in Group V animals, followed by Group IV, Group II and Group III. It may be concluded that therapeutic modulation of redox mechanisms may aid in the clinical management of subclinical diabetes mellitus, however, the mechanisms involved should be further explored.
1 citations
TL;DR: In this paper , the authors evaluated bioactive compounds present in the Ashwagandha (Withania somnifera) root extracts through Ultraviolet-Visible (UV-vis) and Fourier Transform Infra-Red (FTIR) spectroscopy.
1 citations
DOI•
01 Apr 2021
TL;DR: In this article, the authors assessed bioactive compounds, antimicrobial activities and antioxidant studies on different parts of W. somnifera and found that strong antioxidant effect of free radical scavenging activity was recorded at 100µg/ml concentration for ethanol stem and root, methanol leaf extracts (72.22, 80.84, 74.24, and 13.22 mm, respectively).
Abstract: Withania somnifera (L.) Dunal is frequently used as traditional medicine for the treatment of numerous diseases. This study was aimed to assess bioactive compounds, antimicrobial activities and antioxidant studies on different part of W. somnifera. The plant parts were shaded dried and grinded to powders for biological activities. The ethanol, methanol and chloroform extracts were tested for antimicrobial activities. The extracts were subjected to a test of their antimicrobial properties by paper disc diffusion method. Minimum inhibitory concentrations (MICs) of the plant extracts against selected pathogens were also assessed using the agar dilution method. The highest potential was observed from methanol extract of the stem bark and ethanol extract of the leafagainst Staphylococcus aurous with zone of inhibition 15.02 and 13.22 mm, respectively.Alkaloids, steroids, saponins, tannins, reducing sugars, phlobatanins, flavonoids, terpenoids, cardiac glycosides, anthraquinone, emodins and coumarins are result of phytochemical assessment. Strong antioxidant effect of free radical scavenging activity was recorded at 100µg/ml concentration for ethanol stem and root, methanol leaf extracts (72.22%, 80.84%, 74.24%) respectively. Chloramphenicol and DMSO were used as positive and negative controls. W. somnifera could show powerful antimicrobial and antioxidant properties.
1 citations