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Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


Papers
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31 May 2016
TL;DR: Mayer et al. as mentioned in this paper determined biological activity of plants with adaptogenic effect: Panax ginseng, Withania somnifera, Eleuterococcus senticosus, Astragallus membranaceus Fisch and Codonopsis pilosulae Franch.
Abstract: The aim of this study was to determine biological activity of plants with adaptogenic effect: Panax ginseng Mayer., Withania somnifera L., Eleuterococcus senticosus Rupr. et Maxim., Astragallus membranaceus Fisch. and Codonopsis pilosulae Franch. The antioxidant activity was detected by DPPH and phosphomolybdenum method, total polyphenol content with Folin – Ciocalteu reagent, flavonoids content by aluminium chloride method. The detection of antimicrobial activity was carried out by disc diffusion method against three species of Gram-negative bacteria: Escherichia coli CCM 3988, Salmonella enterica subsp. enterica CCM 3807, Yersinia enterocolitica CCM 5671 and two Gram-positive bacteria: Bacillus thuringiensis CCM 19, Stapylococcus aureus subsp. aureus CCM 2461. Results showed that plants with adaptogenic effect are rich for biologically active substances. The highest antioxidant activity by DPPH method was determined in the sample of Eleuterococcus senticosus (3.15 mg TEAC – Trolox equivalent antioxidant capacity per g of sample) and by phosphomolybdenum method in the sample of Codonopsis pilosulae (188.79 mg TEAC per g of sample). In the sample of Panax ginseng was measured the highest content of total polyphenols (8.10 mg GAE – galic acid equivalent per g of sample) and flavonoids (3.41 μg QE – quercetin equivalent per g of sample). All samples also showed strong antimicrobial activity with the best results in Panax ginseng and Withania somnifera in particular for species Yersinia enterocolitica CCM 5671 and Salmonella enterica subsp. enterica CCM 3807. The analyzed species of plant with high value of biological activity can be used more in the future, not only in food, but also in cosmetics and pharmaceutical industries.
Patent
31 Dec 2015
TL;DR: In this article, the authors provide compositions and methods for promoting hair growth and reducing hair loss using bioactive extracts of curcumin, Withania somnifera, and saw palmetto.
Abstract: The invention provides compositions and methods for promoting hair growth and reducing hair loss using bioactive extracts of curcumin, Withania somnifera, and saw palmetto. Tocotrienols, tocopherols, piperine extract, low molecular weight collagen, and hyaluronic acid are optionally included in the compositions and methods.
01 Jan 2014
TL;DR: The effects of Cu + 2 stress on growth and biochemical parameters of Withania somnifera L.Dunal, grown in a field pot experiment were studied as mentioned in this paper, which indicated that Cu+ 2 stress negatively impacted nearly all the parameters assayed, particularly in the roots.
Abstract: The effects of Cu +2 stress (0, 10, 20, 50, 100 and 200 mM as CuSO4.5H2O) on growth and biochemical parameters of Withania somnifera L.Dunal, grown in a field pot experiment were studied. Increasing Cu +2 concentrations led to decreased stem length, root elongation and leaf area. Copper (Cu +2 ) stress decreased chlorophyll and carotenoids content in leaves and stems as compared to controls; this was more pronounced in leaves than in stems. Lipid peroxidation, in terms of malondialdehyde (MDA) content increased. Lipid peroxidation increased significantly with elevation in Cu +2 concentrations and was highest in roots followed by leaves and stems at 200 mM. Leakage of electrolytes measured in terms of membrane stability index (MSI), which showed a negative correlation with increasing Cu +2 levels. The MSI was lowest in 200 mM Cu +2 treated plants. The phenol content of leaves, stems and roots peaked at 50 mM Cu +2 treatment and thereafter declined. These results indicate that Cu + 2 stress negatively impacted nearly all the parameters assayed; particularly in the roots. It is being reported for the first time that stress resistance in W.somnifera as observed by increase in total phenol content at low Cu +2 levels possibly to combat
Journal ArticleDOI
TL;DR: This research highlights the need to understand more fully the role of “spatially aggregated immune checkpoints” in the development of central nervous systems.
Abstract: [This corrects the article DOI: 10.1155/2018/4076430.].

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111