Topic
Withania somnifera
About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.
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TL;DR: Transformed organ cultures of Withania somnifera established following infection with wild type nopaline and octopine strains of Agrobacterium tumefaciens found shooty teratomas of altered phenotype spontaneously developed, finding the main difference was found in the nature of the galls formed and in their subsequent morphological competence.
38 citations
Journal Article•
TL;DR: Oral treatment of W. somnifera exerts protective effect and attenuates AChE inhibition and cognitive impairment caused by sub-chronic exposure to propoxur, a widely used herbal drug possessing anti-stress and immunomodulatory properties.
Abstract: Propoxur (2-isopropoxyphenyl N-methylcarbamate) is widely used as an acaricide in agriculture and public health programs Studies have shown that sub-chronic exposure to propoxur can cause oxidative stress and immuno-suppression in rats Carbamates are also known to exhibit inhibitory effect on cholinesterase activity, which is directly related to their cholinergic effects In the present study, the effect of Withania somnifera (Ashwagandha), a widely used herbal drug possessing anti-stress and immunomodulatory properties was studied on propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function in rats Male Wistar rats were divided into four groups Group I was treated with olive oil and served as control Group II was administered orally with propoxur (10 mg/kg bwt) in olive oil, group III received a combination of propoxur (10 mg/kg bwt) and W somnifera (100 mg/kg bwt) suspension and group IV W somnifera (100 mg/kg bwt) only All animals were treated for 30 days Cognitive behaviour was assessed by transfer latency using elevated plus maze Blood and brain acetylcholine esterase (AChE) activity was also assessed Oral administration of propoxur (10 mg/kg bwt) resulted in a significant reduction of brain and blood AChE activity A significant prolongation of the acquisition as well as retention transfer latency was observed in propoxur-treated rats Oral treatment of W somnifera exerts protective effect and attenuates AChE inhibition and cognitive impairment caused by sub-chronic exposure to propoxur
38 citations
TL;DR: Withania somnifera has yielded two new withanolides, 5-dehydroxywithanolide-R(23β-hydroxy-6α,7α-epoxy-1-oxo-22R-witha-2,24-dienolide) and withasomniferin-A (17-hydrox- 6α, 7α-EPoxy- 1-oxoxo, 22R-Witha-4,24)-dienolate.
38 citations
Journal Article•
TL;DR: Both M. vulgare and W. somnifera protect the rats’ liver against CCl4-induced hepatotoxicity and exhibited significant effects by increasing the GPx, GR and GST activities with increased GSH tissue contents and decreased production of MDA level.
Abstract: Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities of the both extracts against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Both extracts were given orally in a dose of 500 mg/kg/day for 4 weeks along with CCl4 started at the 7th week of induction of hepatotoxicity. The antihepatotoxic activity was assessed by measur-ing aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glutathione peroxidase (GPx), glutathione reduct-ase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH), tissue content and malondialdehyde (MDA) as well as histopathological examination. Both extracts showed a significant antihepatotoxic effect by reducing significantly the levels of AST, ALT and LDH. However, ALP levels were decreased non-significantly. Regarding the antioxidant activity, they exhibited significant effects by increasing the GPx, GR and GST activities with increased GSH tissue contents and decreased production of MDA level. Furthermore, both extracts alleviated histopathological changes in rats' liver treated with CCl4. M. vulgare and W. somnifera protect the rats' liver against CCl4-induced hepatotoxicity. This effect may be attributed, at least in part, to the antioxidant activities of these extracts.
38 citations
TL;DR: Seed explants, Withania somnifera, Micropropagation, and Plant Tissue Cult.
Abstract: Key words: Seed explants, Withania somnifera , Micropropagation DOI = 10.3329/ptcb.v16i2.1112 Plant Tissue Cult. & Biotech. 16(2): 111-115, 2006 (December)
38 citations