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Withania somnifera

About: Withania somnifera is a research topic. Over the lifetime, 2116 publications have been published within this topic receiving 43404 citations. The topic is also known as: Ashwaganda & Indian ginseng.


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Journal ArticleDOI
TL;DR: Findings suggest that the venom PLA(2) has multiple sites on it; perhaps some of them are overlapping.

34 citations

01 Jan 2013
TL;DR: It is demonstrated that Withania somnifera possesses promising hepatoprotective effects through its antioxidant activity and hence suggests its use as a potential therapeutic agent for protection from paracetamol overdose.
Abstract: Objective: The aim of this study was to evaluate the hepatoprotective and antioxidant effects of Withania somnifera against Paracetamol-induced liver injury in rats. Methods: In the present study, the protective effect of Withania somnifera was investigated against Paracetamol-induced hepatotoxicity and compared with Silymarin, a standard hepatoprotective reference drug. The rats received a single dose of paracetamol (900 mg/kg body weight, i.p.); Withania somnifera (500 mg/kg body weight and 1000mg/kg body weight, p.o.) and Silymarin (25 mg/kg body weight, p.o.) were administered 30 min after the injection of paracetamol. Liver marker enzymes (Aspartate Transaminase, Alanine Transaminase and Alkaline Phosphatase), Total Protein content, Bilirubin, Antioxidant status (Reduced Glutathione, Superoxide Dismutase, Catalase and Glutathione-S-Transferase) were evaluated and histopathological analysis was done for the control and experimental rats. Results: Paracetamol treatment leads to elevated levels of liver marker enzymes and bilirubin and there was deterioration in total protein content, histological observations and antioxidant status. However, treatment with Withania somnifera significantly reversed (p < 0.05) the above changes compared to the control group as observed in the paracetamol-challenged rats. Conclusion: The results clearly demonstrate that Withania somnifera possesses promising hepatoprotective effects through its antioxidant activity and hence suggests its use as a potential therapeutic agent for protection from paracetamol overdose.

34 citations

Journal Article
TL;DR: Ethanol extract of C. inerme and W. somnifera can be used for the protection of stored wheat from infestations of S. oryzae and the progeny production was complete by suppressed even in lowest dose.
Abstract: In the present study, ethanol extract of Clerodendrum inerme L. (Verbenaceae), Withania somnifera L. (Solanaceae), Gliricidia sepia L. (Fabaceae), Cassia tora L. (Caesalpiniaceae) and Eupatorium odoratum L. (Asteraceae) were evaluated for their efficacy on mortality and progeny production of rice weevil, Sitophilus oryzae L. (Coleoptera: Curculionidae). Adult insects were exposed to the 2.5 and 5% extracts treated wheat and mortality was assessed after 1, 2, 7, 14 and 21 days. Subsequently, all adults were removed and the treated grains remained at the same conditions for an additional 45 days. After this interval, the commodity was checked for progeny production. All extracts, the beetles mortality was increased in dose dependent manner. Results indicated that C. inerme and W. somnifera extracts were more effective than G. sepia, C. tora and E. odoratum against adult insects. Interestingly, the progeny production (Fl) was complete by suppressed even in lowest dose. It was concluded that both C. inerme and W. somnifera can be used for the protection of stored wheat from infestations of S. oryzae.

34 citations

Journal ArticleDOI
TL;DR: Nachweis, dass auch bei der indischen Varietät vonWithania somnifera «chemische Rassen» with unterschiedlicher Antitumoraktivität in verschiedenen Gegenden auftreten, die jeweils β-Sitosterol enthalten.
Abstract: Nachweis, dass auch bei der indischen Varietat vonWithania somnifera «chemische Rassen» mit unterschiedlicher Antitumoraktivitat in verschiedenen Gegenden auftreten, die jeweils β-Sitosterol enthalten.

34 citations

Journal ArticleDOI
TL;DR: Significant increases were observed in the expression of CD4 on CD3+ T cells after 96 hours of use, indicating that a major change in immune cell activation occurred across the sample.
Abstract: Objective: This study investigated the immunologic effects of Ashwagandha (Withania somnifera) on four types of immune cells in a human sample to determine the immunologic mechanism. Design: Five (5) participants consumed 6 mL of an Ashwagandha root extract twice daily for 96 hours. Ashwagandha was administered with anupana (whole milk). Peripheral blood samples were collected at 0, 24, and 96 hours and compared for differences in cell surface expression of CD4, CD8, CD19, CD56, and CD69 receptors by flow cytometry. Results: Significant increases were observed in the expression of CD4 on CD3+ T cells after 96 hours. CD56+ NK cells were also activated after 96 hours as evidenced by expression of the CD69 receptor. At 96 hours of use, mean values of receptor expression for all measured receptor types were increased over baseline, indicating that a major change in immune cell activation occurred across the sample. Conclusions: Effects on immune cell activation with use of Ashwagandha warrant further...

34 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022265
202188
2020124
201995
2018111